Trizinc bis(hexacyanidocobaltate(III)) dodecahydrate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

July 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP, Guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2015

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

Trizinc bis[hexacyanidocobaltate] dodecahydrate

EC Number:

942-358-9

Cas Number:

69207-66-5

Molecular formula:

Zn3[Co(CN)6]2 ·12H2O

IUPAC Name:

Trizinc bis[hexacyanidocobaltate] dodecahydrate

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Remarks:

1% solution

Doses:

A limit dose of 2000 mg/kg was used as starting dose. The required amount of the test item (according body weight) was mixed with vehicle (carboxymethyl cellulose - 1% solution) shortly before administration.

No. of animals per sex per dose:

Groups of 6 females were dosed (Group of 3 females were dosed. Test item-related mortality was not produced during 24 hours group of 3 females were tested at the same dose).

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD0

Effect level:

>= 5 000 mg/kg bw

Any other information on results incl. tables

All 6/6 females survived the limit dose 2000 mg/kg.

No mortality was observed during the study. Animals lived through observation period without important visible signs of intoxication. Neither change of health nor negative reactions were registered.

The body weights of all animals were increasing during the study. No body weight losses were observed between one and two week after administration.

All animals were necropsied. During necropsy, no macroscopically changes were noticed.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Remarks:

Migrated information

Conclusions:

Based on OECD 423 Annex 2d: Test Procedure with a Starting Dose of 2000 mg/kg Body Weight it can be concluded that the test item Zinc Hexacyanocobaltae Dodecahydrate is classified in Category 5/Unclassified with the cut off LD50 ≥ 5000 mg/kg, after single oral administration to Wistar rats.