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EC number: 607-233-2 | CAS number: 2343-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1/4/15 to 2/7/15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: A recent study, conducted according to an OECD guideline and GLP standards.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- no
- Duration:
- 24 h
- Initial conc. measured:
- 1 g/L
- Preliminary study:
- At pH 4 less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life of greater than 1 year at 25 °C.
At pH 7, the extent of hydrolysis after 4 hours indicated that a further test (Tier 2) was required to estimate the rate constant and half-life at 25 °C.
At pH 9, the extent of hydrolysis after 4 hours indicated that a further test (Tier 2) was required to estimate the rate constant and half-life at 25 °C. - Transformation products:
- not measured
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.096 h-1
- DT50:
- 7.23 h
- pH:
- 7
- Temp.:
- 60 °C
- Hydrolysis rate constant:
- 0.195 h-1
- DT50:
- 3.55 h
- pH:
- 7
- Temp.:
- 70 °C
- Hydrolysis rate constant:
- 0.454 h-1
- DT50:
- 1.53 h
- pH:
- 9
- Temp.:
- 30 °C
- Hydrolysis rate constant:
- 0.385 h-1
- DT50:
- 1.8 h
- pH:
- 9
- Temp.:
- 40 °C
- Hydrolysis rate constant:
- 0.861 h-1
- DT50:
- 0.805 h
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 2.66 h-1
- DT50:
- 0.261 h
- Validity criteria fulfilled:
- yes
- Conclusions:
- Assessment of hydrolytic stability was carried out using a standardised protocol equivalent to the OECD Test Guideline 111.
At pH 4 less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life of greater than 1 year at 25 °C.
At pH 7, the extent of hydrolysis after 4 hours indicated that a further test (Tier 2) was required to estimate the rate constant and half-life at 25 °C.
At pH 9, the extent of hydrolysis after 4 hours indicated that a further test (Tier 2) was required to estimate the rate constant and half-life at 25 °C. - Executive summary:
Assessment of hydrolytic stability was carried out using a procedure designed to be compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The results are as follows:
pH Rate constant (hr-1) Estimated half-life at 25 °C 4 - > 1 year 7 9.98 x 10-3 69.4 hours 9 0.215 3.23 hours
Reference
Description of key information
A reliable study (Klimisch 1) is available to assess the hydrolytic stabilty of 2 -propenoic acid, 2 -fluoro, methyl ester at the environmentally relevant pHs of 4, 7 and 9. The study was conducted to GLP and followed internationally accepted guidelines.
At pH 4 less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life of greater than 1 year at 25°C.
At pH 7 the half-life was estimated to 69.4 hours at 25°C.
At pH 9 the half-life was estimated to be 3.2 hours at 25°C
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 3.2 h
- at the temperature of:
- 25 °C
Additional information
A preliminary assessment of the hydrolytic stability of 2-propenoic acid, 2-fluoro, methyl ester was completed at the environmentally relevant pHs of 4, 7 and 9. The results obtained indicated at pH 4 less than 10% hydrolysis was measured after 5 days at 50°C, equivalent to a half-life of greater than 1 year and no further testing is required. At pHs 7 and 9 the extent of hydrolysis after 4 hours indicated that 2-propenoic acid, 2-fluoro, methyl ester is hydrolytically unstable and half-lives of 69.4 and 3.2 hours at 25°C for pH 7 and 9, respectively, were estimated.
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