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EC number: 208-952-0 | CAS number: 548-61-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 acute oral in the rat is > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: test procedure meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- original language: German
- GLP compliance:
- no
- Test type:
- other: following old standard method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann, Borchen, Germany
- Age at study initiation: 7-9 weeks
- Weight at study initiation: mean males 172 g, mean females 161 g
- Fasting period before study: approximately 16 hours
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days - Route of administration:
- oral: gavage
- Vehicle:
- other: water and cremophor
- Doses:
- 1000, 1500, 1750, 2000, 2500, 3000, 3500, and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 males/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 21 days
- Observation for clinical signs and mortality, feces
- Frequency of weighing: before administration, after one week and et the end of the 14-day observation period - Statistics:
- Probit-Analysis (Fink and Hund, Arzneimittelforschung 15, 624, 1965)
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Probit-Analysis revealed an LD50 of 2057 mg/kg
- Mortality:
- 1000 mg/kg: 0/10
1500 mg/kg: 2/10
1750 mg/kg: 4/10
2000 mg/kg: 5/10
2500 mg/kg: 6/10
3000 mg/kg: 9/10
3500 mg/kg: 9/10
5000 mg/kg: 10/10 - Clinical signs:
- general bad condition
- Body weight:
- reduced at 3500 and 5000 mg/kg bw
- Other findings:
- brown-red feces, increased water consumption and elimination
- Conclusions:
- LD50 was calculated to be greater than 2000 mg/kg bw
- Executive summary:
The acute oral toxicity of the test item was evaluated in a study on male Wistar rats. Single oral doses of 1000 to 5000 mg/kg bw were given to groups of 10 male rats. Mortality occurred at doses of 1500 mg/kg bw and above. The LD50 of the test item was calculated with 2057 mg/kg bw and thus is > 2000 mg/kg bw. According to EU Regulation 1272/2008 no classification for acute oral toxicity is warranted.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Additional information
Justification for classification or non-classification
The acute oral LD50 of the test item in rats is determined with > 2000 mg/kg bw. According to EU Regulation 1272/2008 no classification for acute oral toxicity is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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