Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-006-6 | CAS number: 1719-57-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: DOT Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DOT
- GLP compliance:
- no
Test material
- Reference substance name:
- Dichloro(chloromethyl)methylsilane
- EC Number:
- 216-319-5
- EC Name:
- Dichloro(chloromethyl)methylsilane
- Cas Number:
- 1558-33-4
- IUPAC Name:
- dichloro(chloromethyl)methylsilane
- Reference substance name:
- Silane, dichloro(chloromethyl)methyl-
- IUPAC Name:
- Silane, dichloro(chloromethyl)methyl-
- Details on test material:
- Purity 98 %
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The rabbits were assigned animal numbers using a computerized randomization process. This proc-ess involved generating random numbers, assigning the random numbers to the animals, and rank-ing the random numbers. Using this randomly ranked list, six male rabbits were assigned to this study. The rabbits were identified uniquely by individual ear tags and housed individually in elevated metal cages. Commercial rabbit ration (Purfna Lab Rabbit Chow ,5321) and tap water were available at libitum except where noted otherwise. The rabbits were acclimated to laboratory conditions for a minimum of one week prior to initiation of treatment. Rabbits were used in this study because they have historically been used in safety evaluation studies and are required by appropriate regulatory agencies.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- 0,5 ml
- Duration of treatment / exposure:
- 4 hr
- Observation period:
- none
- Number of animals:
- 6 males
- Details on study design:
- Prior to treatment, the dorsal area of each rabbit was clipped free of hair. and one site was chosen for application. A 0.5 ml aliquot of the test material was introduced onto each intact site under a one by one inch square gauze patch (two layers thick) which was secured in place with transparent tape. The trunk of each rabbit was wrapped with impervious rubber damming. The rabbits were then im-mobilized in stocks for four hours without food and water. Four hours following application, the bind-ers and patches were removed, and the exposure sites were washed with water to preclude further exposure of the animal to the test material. The test material was administered dermally because potential human exposure is by the dermal route.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4 h
- Reversibility:
- not reversible
- Remarks on result:
- other: substance was corrosive to the skin
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The substance is corrosive to the skin
- Executive summary:
The test material chloromethyl-methyl-dichlorosilane. was evaluated for skin corrosivity potential in rabbits following a single dermal application. Extreme blanching and blackened tissue was observed in all rabbits at four hours post application. No edema or other dermal effects were noted. Due to the skin destruction,. the animals were sacrificed four hours after application of test material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.