Registration Dossier
Registration Dossier
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EC number: 238-497-3 | CAS number: 14489-75-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- no data
- Type of information:
- other: Based on another study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: expert judgement
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: GHS Figure 3.3.1 Step 1c - Testing and evaluation strategy for serious eye demage and eye irritation
- Principles of method if other than guideline:
- The conclusion is based on the result of positive skin irratation result with EPISKIN Model.
Test material
- Reference substance name:
- N-methylnaphthalene-1-methylamine
- EC Number:
- 238-497-3
- EC Name:
- N-methylnaphthalene-1-methylamine
- Cas Number:
- 14489-75-9
- Molecular formula:
- C12H13N
- IUPAC Name:
- methyl[(naphthalen-1-yl)methyl]amine
Constituent 1
Results and discussion
In vivo
Results
- Remarks on result:
- other: not relevant
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes)
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- According to Globally Harmonized System of Classification and Labelling of Chemicals document Figure 3.3.1 (Testing and evaluation strategy for serious eye damage and eye irritation) Step 1c: The results of EPISKIN model indicated that the test item is Irritant to skin (I) [EU: R38; UN GHS: Category 2]. Based on the result of in vitro skin irritation test N-methylnaphthalene-1-methylamine (CAS No. 14489-75-9) is classified into eye irritant.
Tiered evaluation for seriuos eye damage/eye irritation in the "Globally Harmonized System of Classification and Labelling of Chemicals" (2013) document, the results (Category 2A) was concluded on the basis of the "In Vitro Skin Irritation Test with “SECONDARY AMINE” (CAS No. 14489-75-9) in the EPISKIN Model" study.
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