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EC number: 908-918-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The acute dermal toxicity of primary amyl acetate was examined with male and female rabbits. The test material was in contact with skin for 24 hours. The application site was examined 1 hour and 7 and 14 days after the contact period.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of 2-methylbutyl acetate and pentyl acetate
- EC Number:
- 908-918-1
- Molecular formula:
- Unspecified
- IUPAC Name:
- Reaction mass of 2-methylbutyl acetate and pentyl acetate
- Details on test material:
- Primary Amyl Acetate (mixture of n-pentyl acetate and 2-methylbutyl acetate)
Clear, non-viscous liquid. No additional information available.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals are maintained on appropriate commercial diet and municipal water. Both are available ad libitum except during periods of restraint.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- New Zealand White rabbits, weighing between 2.0 and 3.0 kg, are immobilized during a 24-hr contact period. The test material is retained under impervious sheeting on the clipped, intact skin of the trunk. Doses are varied by adjusting the volume or weight of the test material. After the contact period, excess fluid is removed to diminish ingestion.
- Duration of exposure:
- 24 hours
- Doses:
- 4.0, 8.0 and 16.0 ml/kg for males or 16.0 ml/kg for females (corresponding to 3502.4, 7004.8 and 14009.6 mg/kg for males and or 14009.6 mg/kg for females, calculated assuming a test substance density of 0.8756 g/ml)
- No. of animals per sex per dose:
- 5 males or 5 females/dose
- Control animals:
- not specified
- Details on study design:
- Test material is applied to the trunk of the rabbits for 24 hours under occlusive conditions. The application site is examined 1 hour and 7 and 14 days after removal of the test material.
- Statistics:
- LD50's are calculated by the moving average method (Thompson, 1947) and are based on a 14-day observation period.
Reference
Thompson, W.R. (1947). Use of moving averages and interpolation to estimate median-effective dose. Bact. Reviews 11:115.
Results and discussion
- Preliminary study:
- Not applicable
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 8 326.96 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 5 693.22 - 14 797.64
- Remarks on result:
- other: calculated from 9.51 ml/kg (5.36-16.9 ml/kg)
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 14 009.6 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male rabbits
16.0 ml/kg: 4 of 5 died. Deaths occurred 1, 1, 2 and 5 days after dosing
8.0 ml/kg: 2 of 5 died. Deaths occurred 2 and 7 days after dosing.
4.0 ml/kg: 0 of 5 died.
Female rabbits
16.0 ml/kg: 1 of 5 died. Death occurred two days after dosing. - Clinical signs:
- other: Male rabbits 16.0 ml/kg: Immediate signs of discomfort (intense squirming and struggling); sluggishness, unsteady gait at 1 day. Prostration before death. Survivor recovered at 5 days. 8.0 ml/kg: Sluggishness, unsteady gait at 1 day. Survivors recovere
- Gross pathology:
- Male rabbits
16.0 ml/kg: In victims, liver with multiple yellow or white foci; intestines red. In survivor, liver with multiple cream-colored foci.
8.0 ml/kg: In victims, lungs of 1 mottled; liver of 1 with cream-colored foci; testes of 1 small; bladder of 1 filled with light red fluid. In survivors lungs of 1 dull dark red, with creamcolored patches, red-tan fluid in thoracic cavity.
4.0 ml/kg: Nothing remarkable
Female rabbits
16.0 ml/kg: In victim, trachea with red patches; liver with multiple white foci and dark dimpling. In survivors, nothing remarkable. - Other findings:
- Clinical signs at application site
Male rabbits
16.0 ml/kg: Erythema immediately; ecchymosis at 1 day; survivor with necrosis, edema, fissuring at 14 days.
8.0 ml/kg: Erythema immediately desquamation at 7 days.
4.0 ml/kg: Erythema immediately desquamation at 7 days.
Female rabbits
16.0 ml/kg: Erythema immediately ecchymosis, desquamation, scab formation at 14 days.
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal toxicity of primary amyl acetate in male and female rabbits was 9.51 and >16.0 ml/kg, respectively.
- Executive summary:
The acute dermal LD50 of primary amyl acetate was examined. The acute dermal toxicity of primary amyl acetate in male and female rabbits was 9.51 and >16.0 ml/kg, respectively.
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