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EC number: 208-060-1 | CAS number: 506-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no hazard identified
Marine water
- Hazard assessment conclusion:
- no hazard identified
STP
- Hazard assessment conclusion:
- no hazard identified
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no hazard identified
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Short-term toxicity to fish:
The acute toxicity of Guanidine Nitrate to fish was tested in toxicity tests against Ictalurus punctatus (Channel catfish), Pimephales promelas (Fathead minnow) peer-reviewed by van der Schalie (1985) and Leuciscus idus (Goldorfe) reported by Adema (1988). The lowest 96-h-LC50 was reported as 690 mg a.i./L in the toxicity test against Pimerphales promelas.
Long-term toxicity to fish:
The chronic toxicity of Guanidine Nitrate was tested in a 35-day fish early life stage test (FELS) against Fathead minnow (van der Schalie, 1985). The NOEC was 181mg/L and the lowest effect concentration was reported at 424mg/L (LOEC).
Short-term toxicity to aquatic invertebrates:
The 48hr-acute toxicity of Guanidine Nitrate to aquatic invertebrates was studied. The immobilization of Daphnids was used as the critical criteria. The study of the acute toxicity of Guanidine Nitrate against Daphnia magna in the report of van der Schalie (1985) shows that the 48-h-EC50, the concentration, in which 50 per cent reduction in immobilization occurs, is 70.2mg/L.
Long-term toxicity to aquatic invertebrates:
The long-term toxicity of Guanidine Nitrate to Daphnia magna was tested in a 21-day flow-through test. The lowest concentration with an effect on reproduction (LOEC) was monitored at a concentration 4.2mg/L in a first chronic test of van der Schalie, 1985 and 6.09mg/L in a second chronic test. The highest concentration of the test item without an effect (NOEC) was found at 2.90mg/L. In another study of Cooney et al. (1985) the 21-day-LOEC was higher (9.95mg/L). It is interesting to mention that Guaninine Nitrate is 10 to 20 times more toxic in a chronic 21-day toxicity test compared to an acute 48h toxicity test which is reported in the same study of van der Schalie, 1985.
Toxicity to aquatic algae and cyanobacteria:
In a 72 hour acute toxicity study (Seibersdorf, 2010), the cultures of Pseudokirchneriella subcapita were exposed to Guanidine Nitrate. The 72h-EC50 values based on growth rate (yield) were 33.5mg a.i./L (11.8 mg a.i./L) and the 72h-NOEC values based on yield (and growth rate) were 6.3 mg a.i./L, respectively.
Toxicity to microorganisms:
The toxicity of Guanidine Nitrate to microorganisms was studied in a 18-h-cell multiplication inhibition test using Pseudomonas putida as test organism (SKW, performed by NOTOX, 1988). Bacterial growth inhibtion was determined by measurement of the turbidity of the bacterial culture.
A 18-h-EC10 of 831.8mg/L was determined.
Toxicity to terrestrial plants
The effect of Guanidine nitrate on germination and growth of wheat seedlings was tested for 14 days. At a Guanidine nitrate concentration of 444 mg/Kg soil (200 µg N/g soil, GuNi 45.9%N; 444 mgGuNi/Kg soil) there was no adverse effect in wheat germination. The response of wheat dry matter production was the same as with urea.
Toxicity to soil microorganisms
The ability of soil microorganism to mineralize guanidine carbon was tested with radiolabelled guanidinium. At a concentration of 96 mg nitrate /Kg soil ww (196 mg Guanidinium nitrate / Kg soil ww), the mineralization rate of guanidinium carbon was 94% of the rate in absence of nitrate. (596 nM mineralized/24hours compared to 634nM mineralized/24hours.) EC4=196mg Guanidinium nitrate / Kg soil ww.
Nitrate showed only a slight tendency to inhibit guanidinium mineralization.
Conclusion on classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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