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Diss Factsheets
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EC number: 200-338-0 | CAS number: 57-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Amongst other exposure related observations in human data, four publications are detailed discussing respiratory irritation potential of monopropylene glycol (Varughese at al 2005, Moline et al 2000, Wieslander 2001 and Wieslander and Norback 2010).
Additional information
The Moline et al. (2000) study evaluated exposure to mixed glycols, including butylene, diethylene, triethylene and monopropylene glycol. No significant acute change in voice quality, pulmonary function, or vocal cord appearance was found. Although actors with exposures to elevated or peak levels of glycols reported more symptoms than actors with less exposure, the mixed nature of the exposures makes it impossible to identify any symptoms as being due to monopropylene glycol exposure.
The Varughese et al. (2005) study also looked at the possible acute and chronic exposure of subjects to glycol theatrical fogs which led to associations between glycol fog uses and decreased pulmonary function with symptoms of coughing and dry throat reported. The mixed nature of the exposures makes it impossible to identify any symptoms as being due to monopropylene glycol exposure.
The Wieslander (2001) study evaluated acute exposure to monopropylene glycol during a 1 minute aviation emergency training exercise. The publication concluded that short exposure to monopropylene glycol mist from artificial smoke generators may cause acute ocular and upper respiratory irritation in non-asthmatic subjects. However, review of these data support different conclusions that no respiratory effects occurred in this study.
The Wieslander and Norback (2010) study evaluated the effects of exposure to monopropylene glycol in professional painters exposed to volatile organic compounds and microbial volatile organic compounds in water based paints. The publication concluded that house painters may have a risk of physiological reactions in the ocular and nasal mucosa. However, the mixed nature of the exposures makes it impossible to identify any symptoms as being due to monopropylene glycol exposure.
The human exposure data available showing possible respiratory effects of monopropylene glycol, are detailed and critiqued in full in the endpoint study summary for irritation / corrosion (IUCLID section 7.3).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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