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EC number: 201-081-7 | CAS number: 78-08-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 May to 27 Aug 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Triethoxy(vinyl)silane
- EC Number:
- 201-081-7
- EC Name:
- Triethoxy(vinyl)silane
- Cas Number:
- 78-08-0
- Molecular formula:
- C8H18O3Si
- IUPAC Name:
- triethoxy(vinyl)silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Labs Inc., Portage, MI, USA
- Age at study initiation: 8-12 wk
- Weight at study initiation: 216-349 g
- Fasting period before study: 18-20 h
- Housing: 1/suspended wire mesh cage
- Diet: certified rodent LabDiet5002, PMI Nutrition International, ad libitum
- Water: municipal water, ad libitum
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.6 to 22.3
- Humidity (%): 41.3-61.0
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From 1998-05-13 To 1998-06-12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5.56 ml/kg bw
- Doses:
- 3846, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation for mortality 1, 3, 4 h, then twice daily for 14 days; clinical observations 1, 3, 4 h then daily for 14 days; body weights on days -1, 0, 7, 14.
- Necropsy of survivors performed: yes, the major organ systems of the cranial, thoracic and abdominal cavities were examined for all animals. - Statistics:
- None given.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Dose-related mortality. 2 males and 1 female died at the highest tested dose of 5000 mg/kg bw, and 2 females of the lower dose group died. (See also table below.) All deaths occured within four days of dosing.
- Clinical signs:
- other: The majority of animals had wet or dry deposits round the mouth, anogenital or urogenital areas, or on the trunk or limbs. Impaired coordination, hypoactivity and tremors occured in both sexes. Mucoid faeces, ocular discharge or laboured breathing occured
- Gross pathology:
- No clear treatment-related effect. One female that died had an unspecified 'white precipitate' in the kidneys. At terminal necropsy no gross findings for any animal were observed.
Any other information on results incl. tables
Table 1: Number of animals dead and with evident toxicity, and time range within which mortality occurred
Dose |
Mortality (# dead/total) |
Time range of deaths (days) |
Number with evident toxicity (#/total) |
|||||
Male |
Female |
Combined |
Male |
Female |
Combined |
|||
3846 |
0/5 |
2/5 |
2/10 |
0-4 |
Impaired coordination Hypoactive Tremors mucoid faeces Ocular discharge Laboured breathing |
2/5 3/5 0/5 0/5 0/5 0/5 |
5/5 4/5 4/5 0/5 2/5 1/5 |
7/10 7/10 4/10 0/10 2/10 1/10 |
5000 |
2/5 |
1/5 |
3/10 |
3-4 |
Impaired coordination Hypoactive Tremors mucoid faeces Ocular discharge Laboured breathing |
5/5 4/5 1/5 1/5 0/5 0/5 |
5/5 2/5 2/5 0/5 4/5 0/5 |
10/10 6/10 3/10 1/10 4/10 0/10 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008
- Conclusions:
- In an acute oral toxicity study conducted in compliance with the now deleted OECD 401, and in accordance with GLP, an LD50 in excess of 5000 mg/kg bw was identified. There was evidence of systemic toxicity at 5000 and 3846 mg/kg bw; impaired muscle coordination, hypoactivity, tremors and clear ocular discharge. Mucoid feces and laboured breathing were each noted for animals that died. All surviving animals appeared normal by day 13 of the observation period.
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