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EC number: 231-105-1 | CAS number: 7439-96-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed journal
- Justification for type of information:
- Data is from Peer reviewed journal.
- Qualifier:
- according to guideline
- Guideline:
- other: ISO (International Standardization Organization) Soil Quality- Inhibition of Reproduction ofCollembola (Folsomia candida)
- Principles of method if other than guideline:
- To determine toxicity of test chemical to soil micro-organism in accordance with ISO (International Standardization Organization) Soil
Quality- Inhibition of Reproduction ofCollembola (Folsomia candida) guideline - GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Test organisms (inoculum):
- soil
- Total exposure duration:
- 4 wk
- Test temperature:
- 20°C
- Moisture:
- 90%
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass test containers
- Material, size, headspace, fill volume: 42 mm ID; 45 mm deep
- No. of organisms per vessel: 10-12 day-old juveniles
- No. of vessels per control (replicates): Five replicates
- No. of vessels per concentration (replicates): Five replicates
-Other : The test chambers were randomly placed in an incubator at 20°C with a relative humidity of90%. - Nominal and measured concentrations:
- nominal : 0, 10, 18, 31, 54, 94, 164, 287, and 503 mg/kg
- Reference substance (positive control):
- yes
- Remarks:
- Prentox® carbarnate (0.05 mg kg-1)
- Key result
- Duration:
- 4 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 444 mg/kg soil ww
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- respiration rate
- Duration:
- 4 wk
- Dose descriptor:
- other: LOEC
- Effect conc.:
- 2 444 mg/kg soil ww
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- respiration rate
- Duration:
- 4 wk
- Dose descriptor:
- other: EC20
- Effect conc.:
- 1 209 mg/kg soil ww
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- respiration rate
- Duration:
- 4 wk
- Dose descriptor:
- EC50
- Effect conc.:
- 1 663 mg/kg soil ww
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- respiration rate
- Details on results:
- The 4 weeks NOEC, LOEC value was determined to be 2444 mg/kg and EC20, EC50 value 1209 mg/kg , 1663 mg/kg respectively.
- Reported statistics and error estimates:
- Analysis of Variance (ANOVA)
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 4 weeks NOEC, LOEC value was determined to be 2444 mg/kg and EC20, EC50 value 1209 mg/kg , 1663 mg/kg respectively.
- Executive summary:
Aim of this study was to determined the effect of test chemical on the mortality of Folsomia candida(soil micro-organism).Test was conducted for 4 week. A natural soil, Sassafras sandy loamwas used in this study to assess the toxicity oftest chemicals to F. candida.The soil was sieved through a 5mm2 mesh screen, air-dried for at least 72 h and mixed periodically to ensure uniform drying, passed through a 2-mm sieve, and stored at room temperature before use in testing. This soil was 71 % sand, 18% silt, 11 % clay, a CEC of 4.27 crnol/kg, pH of 5.0 and an organic matter content of 1.2% The culture of micro-organism was maintained in culture jars on a mixture of charcoal and plaster of Paris in the dark at 20°C and fed withcattle manure spiked with Mn at 151.7 mg/kg. The positive control used in these studies was Prentox carbarnate(0.05 mg/kg) and the Concentrations for Mn were 100, 500, 1000, 5000 and 10000 mg kg-1.Five replicates were used for each treatment concentration and controls. Nominal Mn treatment concentrations included 0, 10, 18, 31, 54, 94, 164, 287, and 503 mg kg" 1. Ten-to-twelve day-old juveniles are exposed to a range of concentrations of the test chemical added to soil. Inductively coupled plasma mass spectrometry (ICP-MS) was used to identification and detection of test chemical. Analyses of test chemical concentrations were conducted using a Perkin-Elmer 5100 PC Atomic Absorption Spectrophotometer equipped with an AS-90 auto-sampler. Test substance was extracted from soil using0.05MCaCl2with agitation on a reciprocating shaker for 24h. Analysis of Variance (ANOVA) was used to determine the bounded No Observed Effect Concentration (NOEC) and Lowest Observed Effect Concentration (LOEC) values for test organism. Manganese did not affect adult springtail survival at the 1667 mg/kg concentration (NOEC). Adult survival was significantly reduced at 2444 mg/kg (LOEC).The bounded NOEC for juvenile production was 1067 mg/kg and the bounded LOEC for juvenile production was 1100 mg/kg.
Reference
Results of chemical analyses (following a 3-week weathering/aging procedure) for total Mn amended individually in SSL soil. Measured concentrations were determined using USEPA Method 200.8 and inductively coupled plasma mass spectrometry (ICP-MS).
Manganese |
||
Nominal (mg/kg) |
Measured(mg/kg) |
Recovery(%) |
0 |
94 |
|
287 |
386 |
102** |
500 |
633 |
108 |
695 |
1067 |
140 |
966 |
1100 |
104 |
1343 |
1667 |
117 |
1867 |
2444 |
126 |
2594 |
2836 |
106 |
3606 |
3667 |
99 |
5013 |
5056 |
99 |
Description of key information
The 4 weeks NOEC, LOEC value was determined to be 2444 mg/kg and EC20, EC50 value 1209 mg/kg , 1663 mg/kg respectively.
Key value for chemical safety assessment
Additional information
Following study includes experimental study for the target chemical to observe the toxicity of test chemical to soil micro-organism as follows:
Aim of this study was to determined the effect of test chemical on the mortality of Folsomia candida(soil micro-organism).Test was conducted for 4 week. A natural soil, Sassafras sandy loamwas used in this study to assess the toxicity oftest chemicals to F. candida.The soil was sieved through a 5mm2 mesh screen, air-dried for at least 72 h and mixed periodically to ensure uniform drying, passed through a 2-mm sieve, and stored at room temperature before use in testing. This soil was 71 % sand, 18% silt, 11 % clay, a CEC of 4.27 crnol/kg, pH of 5.0 and an organic matter content of 1.2% The culture of micro-organism was maintained in culture jars on a mixture of charcoal and plaster of Paris in the dark at 20°C and fed withcattle manure spiked with Mn at 151.7 mg/kg. The positive control used in these studies was Prentox carbarnate(0.05 mg/kg) and the Concentrations for Mn were 100, 500, 1000, 5000 and 10000 mg kg-1.Five replicates were used for each treatment concentration and controls. Nominal Mn treatment concentrations included 0, 10, 18, 31, 54, 94, 164, 287, and 503 mg kg" 1. Ten-to-twelve day-old juveniles are exposed to a range of concentrations of the test chemical added to soil. Inductively coupled plasma mass spectrometry (ICP-MS) was used to identification and detection of test chemical. Analyses of test chemical concentrations were conducted using a Perkin-Elmer 5100 PC Atomic Absorption Spectrophotometer equipped with an AS-90 auto-sampler. Test substance was extracted from soil using0.05MCaCl2with agitation on a reciprocating shaker for 24h. Analysis of Variance (ANOVA) was used to determine the bounded No Observed Effect Concentration (NOEC) and Lowest Observed Effect Concentration (LOEC) values for test organism. Manganese did not affect adult springtail survival at the 1667 mg/kg concentration (NOEC). Adult survival was significantly reduced at 2444 mg/kg (LOEC).The bounded NOEC for juvenile production was 1067 mg/kg and the bounded LOEC for juvenile production was 1100 mg/kg.
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