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Diss Factsheets
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EC number: 211-309-7 | CAS number: 637-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A QSAR-derived permeability coefficient (Kp) for ETBE was available. Furthermore, an experimentally derived Kp for MTBE, a highly similar substance, was available. The QSAR-derived Kp was 0.0063 cm/hour and the experimentally derived Kp of MTBE was 0.0035 cm/hour after correction for the higher temperature. For the calculation of the percentage absorption, the aqueous Kp of 0.0063 cm/hour was used.
Key value for chemical safety assessment
- Absorption rate - dermal (%):
- 0.3
Additional information
Absorption and distribution
ETBE is rapidly absorbed and distributed into the blood after inhalation exposure. In humans, the respiratory uptake of ETBE was 32-34%. Absorption becomes saturated at higher concentrations in rats and mice (> 1750 ppm).
Metabolism
Tert-butyl alcohol (TBA), a TBA conjugate, 2-methyl-1,2-propanediol, and 2-hydroxyisobutyrate were found to be metabolites of ETBE in rats and humans. In addition, trace amounts of acetone were present in urine.
After inhalation exposure of 4 and 40 ppm of ETBE, urinary excretion of metabolites was less in the rats than in humans exposed under identical conditions and urinary half-lives in rats were also shorter than in humans. Unchanged ETBE was not detected in rat urine, but it was present in human urine.
Elimination
Elimination is mainly in urine and exhalation and most of the elimination takes place during the first two days in both rodent species. The elimination in urine is mainly in 2-hydroxyisobutyrate. ETBE is exhaled more than TBA shortly after the exposure but later TBA becomes prominent. ETBE was eliminated from the blood with a half-life of 0.4-0.6 hr.
Information used for DNEL derivation
The inhalation and dermal absorption percentages used for DNEL derivation (in case of route-to-route extrapolation) are 40% and 0.3%, respectively. No data on oral absorption for ETBE is available. However, based on the available data for the two structure analogues MTBE and TAME, 100% oral absorption is assumed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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