Propan-2-ol

Sediment toxicity

Link to relevant study record(s)

Reference

Endpoint:

sediment toxicity: long-term

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2021

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Detailed information covering the calculation model and the physico-chemical data used as input are in the attached document.

The target lipid model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. The TLM has been applied to soils and sediment using equilibrium partitioning (EqP) model. This framework utilizes organic carbon partition coefficients (KOC) to convert aquatic based effect levels (CW) to bulk soil- and sediment-based effect levels. The combined TLM-EqP framework was validated previously for soil and sediment acute and chronic toxicity endpoints. The substance is considered within the scope of the TLM and EqP frameworks.

Principles of method if other than guideline:

The target lipid model (2015) and equilibrium partitioning model as described in the cited references were used to determine soil or sediment effect levels following an estimation of initial loading of the registered substance in the substrate. A full explanation of the calculation method is provided in the 'attached justification'.
For model description and justification of QSAR prediction: see fields 'justification for type of information' and 'attached justification'

Test organisms (species):

Lumbriculus variegatus

Duration:

28 d

Dose descriptor:

other: LL50

Effect conc.:

241 mg/kg sediment dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Duration:

28 d

Dose descriptor:

other: NOELR

Effect conc.:

46.2 mg/kg sediment dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Remarks:

biomass

Remarks on result:

other: chronic endpoints were estimated using typical acute-to-chronic ratio of 5.22 (McGrath et al., 2018)

See attachment "Petrotox_EqP_Soil-Sed_Calculation.xlsx" in Section 13.2 of IUCLID

Conclusions:

The target lipid model (2015) and equilibrium partitioning model as described in the cited references were used to determine sediment effect levels following an estimation of initial loading of the registered substance in the substrate. The 2-propanol estimated 28-day LL50 value is 25.83 mg/kg sediment dw based on mortality and the NOELR value is 4.95 mg/kg sediment dw based on reproduction/biomass for the sediment species Lumbriculus variegatus. The values were estimated using the Petrotox computer model.

Executive summary:

The target lipid model (TLM) has been applied to soils and sediment using equilibrium partitioning (EqP) model. As such, modeled data are considered fit for purpose.

Description of key information

A QSAR using the Target Lipid Model (TLM) and the Equilibrium Partitioning Model (EqP) reported long-term LL₅₀ and NOELR values of 241 mg/kg sediment dry weight and 46.2 mg/kg sediment dry weight, respectively for Lumbriculus variegatus.

Key value for chemical safety assessment

EC50 or LC50 for freshwater sediment:

241 mg/kg sediment dw

EC10, LC10 or NOEC for freshwater sediment:

46.2 mg/kg sediment dw

Additional information

The target lipid model (TLM) has been applied to soils and sediment using equilibrium partitioning (EqP) model. As such, modelled data are considered fit for purpose.

Detailed information covering the calculation model, physico-chemical data used as input and the results are attached in section 13.2 of IUCLID.

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