Registration Dossier
Registration Dossier
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EC number: 231-441-9 | CAS number: 7550-45-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The result is sourced from secondary literature ([IUCLID 2000 data set). The original reference was not available for review.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicology of Titanium Tetrachloride
- Author:
- Sanotskii, IV
- Year:
- 1 960
- Bibliographic source:
- Prom. Toksikol. Moscow, Sb. 213-219 as cited in IUCLID 2000
Materials and methods
- Principles of method if other than guideline:
- No details available.
Test material
- Reference substance name:
- Titanium tetrachloride
- EC Number:
- 231-441-9
- EC Name:
- Titanium tetrachloride
- Cas Number:
- 7550-45-0
- Molecular formula:
- Cl4Ti
- IUPAC Name:
- titanium tetrachloride
- Details on test material:
- No details available.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Results and discussion
In vivo
- Irritant / corrosive response data:
- One drop of liquid TiCl4 applied for 10 seconds with subsequent copious washing with water caused suppurative conjunctivitis and darkening of the cornea. Application of solid hydrolysis product TiCl(OH)3 caused slight irritation of the conjunctiva. Aqueous hydrolysis product caused hyperemia of the conjunctiva.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Severe eye damage was observed following a short exposure to undiluted TiCl4. This is consistent with classification of the substance as corrosive.
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