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EC number: 243-001-3 | CAS number: 19372-44-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 14 - December 13, 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to OECD guideline and GLP. No CoA included in the report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- - a maximum dose volume of 20 ml/kg was used for a non aqueous solution, 10 ml/kg is recommended.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(pentane-2,4-dionato)calcium
- EC Number:
- 243-001-3
- EC Name:
- Bis(pentane-2,4-dionato)calcium
- Cas Number:
- 19372-44-2
- Molecular formula:
- C10H14CaO4
- IUPAC Name:
- calcium bis[(2Z)-4-oxopent-2-en-2-olate]
- Details on test material:
- Name: Ca-Acetylacetonate
Batch No.: 106002
Physical state: Powder
Purity: 98%
No CoA included in the report.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Zentralinstitut fur verzuchstierzucht GmbH
- Age at study initiation: no data
- Weight at study initiation: m: 239-271g f: 150-180g
- Fasting period before study: yes, from 16 hours before until 3-4 hours after the study
- Housing: collective housing up to a maximum of 5 animals per cage (Macrolon typy III)
- Diet (e.g. ad libitum): ad libitum, Ssniff Spezialdiaten GmbH
- Water (e.g. ad libitum): ad libitum, drinking water as for human consumption
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: November 14 - December 13, 1991
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 5% and 7.5% suspension
- Amount of vehicle (if gavage): 20 ml/kg
- Justification for choice of vehicle: no data
- Lot/batch no. (if required): no data
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED: 20 ml/kg - Doses:
- Range finding: 2000, 1500, 1000 mg/kg bw
Final study: 1500, 1000 mg/kg bw - No. of animals per sex per dose:
- Range finding: 2 females
Final study: 5 - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were examined at the following post-treatment intervals 10 min., 30 min., 1, 2, 6, 24 hoours and daily thereafter once daily up to day 14. The body weights were recorded immedialtly before treatment (day 0) and surviving animals were reweighed on day 7 and 14.
- Necropsy of survivors performed: yes - Statistics:
- LD50 values were calculated accoring to methods of linear regression.
Results and discussion
- Preliminary study:
- There were 4 deaths in the preliminary study. 0 at 1000 mg/kg bw, 2 at 1500 mg/kg bw and 2 at 2000 mg/kg bw.
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 417 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 250 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died at 1000 mg/kg bw. All males died at 1500 mg/kg bw and 3 females died at 1500 mg/kg bw.
- Clinical signs:
- other: Severe abonormal clinical intoxication signs were observed up to 24h p.a. The most frequent findings were reduced activity, abnormal body posture, decreased body and abdominal tone, impaired respiration, tremor, tonic and clonic convulsions.
- Gross pathology:
- Surviving animals showed no abnormalities at necropsy. Animals found dead showed; redness and swelling of the gastric mucous membrane, congestion in liver and lung, urinary retention, dicoloration of the renal pelvis and spleen.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 male 1250 mg/kg, females 1417 mg/kg.
- Executive summary:
The acute oral toxicity of Ca-Acetylacetonate was investigated in 2 groups of Wistar rats, each containing 5 males and 5 females. On the basis of the range finding results, the animals were given a single oral administration at doses of 1000 mg/kg and 1500 mg/kg. Clinical observations were conducted at regular intervals during the 14 -day observation period. Body weights were measured 0, 7 and 14 days p.a. Gross pathological examinations were performed immediatly on animals found dead or killed in extremis and at termination on surviving animals.
None of the animals died at 1000 mg/kg bw. All males died at 1500 mg/kg bw and 3 females died at 1500 mg/kg bw. Severe abonormal clinical intoxication signs were observed up to 24h p.a. The most frequent findings were reduced activity, abnormal body posture, decreased body and abdominal tone, impaired respiration, tremor, tonic and clonic convulsions. Weight gains were normal in all surviving animals. Surviving animals showed no abnormalities at necropsy. Animals found dead showed; redness and swelling of the gastric mucous membrane, congestion in liver and lung, urinary retention, dicoloration of the renal pelvis and spleen.
The LD50 for males is 1250 mg/kg and for females is 1417 mg/kg .
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