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EC number: 240-347-7 | CAS number: 16219-75-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Basic data given. Meets generally accepted scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Mammalian Toxicity of Ethylidenenorbornene [5-Ethylidenebicyclo(2,2, 1)hept-2-ene]
- Author:
- KINKEAD ER, POZZANI UC, GEARY DL, AND CARPENTER CP
- Year:
- 1 971
- Bibliographic source:
- Toxicol Appl Pharmacol 20: 250-259
Materials and methods
- Type of study / information:
- Odor threshold and sensory response
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5-ethylidene-8,9,10-trinorborn-2-ene
- EC Number:
- 240-347-7
- EC Name:
- 5-ethylidene-8,9,10-trinorborn-2-ene
- Cas Number:
- 16219-75-3
- Molecular formula:
- C9H12
- IUPAC Name:
- 5-ethylidenebicyclo[2.2.1]hept-2-ene
- Details on test material:
- - Name of test material (as cited in study report): Ethylidenenorbornene [5-Ethylidenebicyclo(2,2, 1)hept-2-ene]
Constituent 1
Method
- Ethical approval:
- not specified
- Exposure assessment:
- estimated
- Details on exposure:
- Odour Theshold:
In order to ascertain the odour threshold of ENB vapour for human beings, a group of 6 volunteers between 22 and 49 years of age sniffed a series of concentrations for approximately 10 seconds. The series consisted of 3 vapour concentrations and 1 control air concentration, breathed in random order on 2 occasions. This was accomplished in a glass-lined 12,800 L room through which the vapour-air mixture was moved at 2000-3200 L/min. The vapour concentrations were not analyzed for this series of inhalations, but they are reported as corrected concentrations. (These metered concentrations are reduced 44 % to match the mean percent recovery in the repeated inhalation animal study.) The volunteers, who were neither screened nor selected for their olfactory prowess had no knowledge of the concentrations they were inhaling. The intervals between each concentration were at least 45 min.
Sensory Response:
To determine the human sensory response to ENB vapor, 2 male subjects inhaled a corrected concentration of 11.2 ppm, and 4 subjects (3 males and 1 female) inhaled a corrected concentration of 5.6 ppm for 30-min intervals.
Results and discussion
Any other information on results incl. tables
Odour Threshold:
The responses for 10-sec inhalation periods are summarized below:
Corrected concentrations (ppm) |
0.028 |
0.014 |
0.007 |
0.0 |
Number of subjects |
6 |
6 |
6 |
6 |
Number of trials |
2 |
2 |
2 |
2 |
Incidence of odour detection(%) |
100 |
100 |
0 |
8.3 |
The odor threshold of ENB vapor for human beings appears to be between a corrected 0.014 ppm and 0.007 ppm.
Sensory Response:
Both subjects detected the odor of 11.2 ppm for the entire 30-min exposure. One subject experienced transitory eye and nose irritation at 21 min and eye irritation again at 30 min. One subject reported tasting the vapor during the exposure, and both thought they could taste the material for approximately 10 min after leaving the exposure chamber. One also mentioned slight throat irritation during the first 10 min postexposure. The 4 subjects inhaling 5.6 ppm were able to detect the odor for the entire 30 min. Three subjects, including the female, reported transitory eye irritation, and I male reported tasting the material sporadically. At the start of exposure I male reported a slight dizzy sensation which lasted less than 2 min. Three subjects, including the female, reported tasting the chemical for 10-15 min after the exposure.
Applicant's summary and conclusion
- Executive summary:
Kinkead et al. (1971) published results of human volunteer exposures designed to investigate odour threshold and sensory irritation.
The odour threshold was estimated in six volunteers (22-49 years) who sniffed a series of ENB vapour concentrations for ca. 10 seconds in random order. All volunteers detected odour at 0.028 and 0.014 ppm, but none at 0.007 ppm. This small series suggests that the odour threshold for ENB was between 0.007 and 0.014 ppm.
Peripheral sensory irritant effects were studied in a few subjects exposed to either 5.6 or 11.2 ppm ENB vapour. At 11.2 ppm, two subjects detected the odour over a 30-min exposure period. One subject had transient nose and eye irritation at 21 min, and a repeat of eye irritation at 30 min. At 5.6 ppm all of four subjects detected the odour, three had transient eye irritation and one had a slight dizzy sensation. Based on this limited information, the human sensory irritant threshold appears to be ca. 5 ppm.
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