Registration Dossier
Registration Dossier
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EC number: 200-909-4 | CAS number: 75-86-5
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Adequacy of study:
- other information
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Berteau PE, Levinskas GJ, Rodwell ED. (1982)|Teratogenic effects of aliphatic nitriles in rats.|Toxicologist 2(1) 118
- Title:
- No information
- Author:
- Monsanto Co. (1982)|Range finding teratology study in the rat: Monsanto Co.|Report IL-83-094. US EPA/OPTS Public file No. 878216399.
- Title:
- No information
- Author:
- Monsanto Co. (1983)|Report IL-83-105 Teratology study in rats US EPA/OPTS Public|files No. 878216401
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-hydroxy-2-methylpropionitrile
- EC Number:
- 200-909-4
- EC Name:
- 2-hydroxy-2-methylpropionitrile
- Cas Number:
- 75-86-5
- Molecular formula:
- C4H7NO
- IUPAC Name:
- 2-hydroxy-2-methylpropanenitrile
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: gavage
- Frequency of treatment:
- daily (gd 6 through 15)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1, 3 & 10 mg/kg/day
Basis:
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Sex: female
Duration of test: 9 days
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 1 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 10 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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