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EC number: 403-360-0 | CAS number: 42405-40-3 BONTRON E-84; E-84
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study, only basic data available from SNIF (ECHA)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 84/449/EEC, Method B1 OECD Guideline No. 401
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 610-025-4
- EC Number:
- 610-025-4
- IUPAC Name:
- 610-025-4
- Reference substance name:
- Bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
- EC Number:
- 403-360-0
- EC Name:
- Bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
- Cas Number:
- 42405-40-3
- Molecular formula:
- C30H42O6Zn
- IUPAC Name:
- bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
Constituent 1
Constituent 2
Test animals
- Species:
- other: Rat, Sprague-Dawley
Administration / exposure
- Vehicle:
- other: 1% Carboxymethylcellulose in distilled water
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 800 mg/kg bw
- 95% CL:
- 1 400 - 2 200
- Remarks on result:
- other: Slope of the mortality curve: 4
- Mortality:
- Male: 500 mg/kg bw; Number of animals: 7; Number of deaths: 0
Male: 800 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1000 mg/kg bw; Number of animals: 2; Number of deaths: 2
Male: 1260 mg/kg bw; Number of animals: 5; Number of deaths: 3
Male: 2000 mg/kg bw; Number of animals: 10; Number of deaths: 7
Male: 2500 mg/kg bw; Number of animals: 2; Number of deaths: 2
Male: 3200 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 5000 mg/kg bw; Number of animals: 10; Number of deaths: 6
Male: 8000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 500 mg/kg bw; Number of animals: 7; Number of deaths: 0
Female: 800 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 1000 mg/kg bw; Number of animals: 2; Number of deaths: 1
Female: 1260 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 2000 mg/kg bw; Number of animals: 10; Number of deaths: 5
Female: 2500 mg/kg bw; Number of animals: 2; Number of deaths: 1
Female: 3200 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 5000 mg/kg bw; Number of animals: 10; Number ofdeaths: 7
Female; 8000 mg/kg bw; Number of animals: 5; Number ot deaths: 5 - Clinical signs:
- Signs of toxicity related to dose levels:
Mortalities:
Mortalities occurred amongst rats dosed at 1260 mg/kg and
above, within 1 and 47 hours after dosing.
Clinical signs:
Signs of reaction to treatrrient shortly after dosing in all
rats were pilo-erection and lethargy.
These were accompanied amongst rats from all groups by hunched posture, abnormal gait, decreased respiratory rate and pallor of the extremities.
Increased salivation was observed in all female rats dosed
at 5000 mg/kg and two female rats at 8000 mg/kg.
A comatose like condition was observed amongst rats dosed at
2000 mg/kg and above.
Gasping was observed in one female rat dosed at 5000 mg/kg and one female dosed at 8000 mg/kg.
Noisy respiration was observed in one female at 5000 mg/kg and two females at 8000 mg/kg.
Recovery, as judged by external appearance and behaviour,
was apparently complete by day 5. - Gross pathology:
- Effects on Organs:
Autopsy of animals that had died during the study revealed
pallor of the kidneys and spleen.
Occasional incidences of haemorrhagic lungs, pallor and
patchy livers and pale lungs ware also observed.
Terminal autopsy findings were normal.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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