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EC number: 246-466-0 | CAS number: 24800-44-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The calculated half life of tripropylene glycol is 0.19 days with a OH radical concentration of 1.5E6 OH/cm3 (Aopwin, 2000).
In accordance with column 2 of REACH Annex VIII, the hydrolysis test does not need to be conducted as the substance is readily biodegradable. Furthermore, ethers and glycols are generally known to be resistant to hydrolysis (Harris, J.C., 1990). Therefore, the substance is not expected to undergo hydrolysis under environmentally relevant conditions. No photodegradation in water is expected, because of lack of UV absorption (OECD SIDS, 1994)
Four reliable screening tests (GLP compliant guideline studies) and a non-GLP result from the MITI database are available which show different results on the biodegradability of the substance. In the OECD Guideline 301 F test (Ready Biodegradability: Manometric Respirometry Test) with sludge from a municipal sewage treatment plant, 81.9% biodegradation was found after 28 days determined as O2 consumption and 60.1% determined as CO2 removal (The Dow Chemical Company, 2003). This test is a better simulation of realistic conditions than the other screening tests and will therefore be further used as key study in the assessment. It can be concluded that the substance is ready biodegradable.
Under the conditions of other screening tests (OECD301B, OECD301C and OECD301D with municipal inoculum) the test substance was not ready biodegradable (Shell Research, 1993, MITI, 1995, The Dow Chemical Company, 1991). However, in an OECD301D test with industrial inoculum, 69% of the theoretical oxygen demand was consumed after 28 days in reaction mixtures containing the industrial inoculum. These data suggest that some adaptation of the microorganisms may be required for biodegradation. Significant biodegradation was found in an OECD306 test with natural seawater after 64 days (West, 2007). Therefore tripropylene glycol is not expected to persist in water or marine environments. Simulation studies with sediment and/or soil are not available.
The rate constant used in the assessment are (EUSES calculations):
Degradation for hydrolysis |
6.93E-07 d-1 |
Degradation for photolysis |
6.93E-07 d-1 |
Degradation in air |
0.19 d-1 (QSAR calculation) |
Degradation in the STP |
24 d-1 |
Biodegradation in water |
0.0462 d-1 |
Biodegradation in sediment |
2.31E-03 d-1 |
Biodegradation in soil |
0.0231 d-1 |
Based on the result of the octanol/water partition coefficient (log Kow = -0.379) tripropylene glycol is expected to have a low potential for bioaccumulation and adsorption/desorption.
The calculated Henry's law constant at environmental relevant temperature is 0.129 Pa.m3/mol using EUSES calculation (The European Union System for the Evaluation of Substances, 2008)
Volatility is not expected to be a significant fate process due to its low vapor pressure and high water solubility.
Using fugacity modelling (Mackay level IIII) tripropylene glycol will preferentially partition into water (9%), soil (34%) and sediment (57%) if released into the environment (OECD SIDS, 1994).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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