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EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-01-23 to 1984-10-.29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conduction and documentation of study very acceptable. Study report available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- pentane-2,4-dione
- Details on test material:
- - Name of test material (as cited in study report): 2,4-Pentanedione
- Physical state: liquid
- Stability under test conditions: stable
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Kingston, NY, USA
- Age at study initiation: 26-38 days old
- Fasting period before study: not reported
- Diet (e.g. ad libitum): not reported
- Water (e.g. ad libitum): not reported
- Acclimation period: approx. 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Groups of 5 male and 5 female Hilltop-Wistar albino rats [HLA(WI)BR] were exposed for four hours to dynamically generated vapour of 2,4- pentanedione. Concentrations tested were 628, 919, 1231 and 1508 ppm (corres ponding to 2619; 3823; 5133 and 6288 mg/m³, respectively). Chamber concentrations concurrently analysed throughout each 4-hour exposure by GC.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gas chromatography
- Duration of exposure:
- 4 h
- Concentrations:
- 628, 919, 1231 and 1508 ppm (corresponding to 2619; 3823; 5133 and 6288 mg/m³).
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Postexposure period 14 d; body weight determined at 0, 7 an d 14 d postexposure. A static exposure was also performed for determination of LT50. Groups of 5 male and 5 female rats were exposed to 7732 and 6388 ppm (correspond-ing to 32242 and 26638 mg/m³) for 74 and 37 minutes (males) and 8374 and 7449 ppm (corresponding to 34920 and 31062 mg/m³ for 78 and 39 minutes (females).
- Statistics:
- not reported
Results and discussion
- Preliminary study:
- not reported
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 1 224 ppm
- Based on:
- test mat.
- 95% CL:
- 1 063 - 1 409
- Exp. duration:
- 4 h
- Mortality:
- in exposure gruops of 1231 ppm upwards
- Clinical signs:
- other: periocular, perinasal and perioral wetness and encrustation, forced respiration, dis-tended abdomen, tremors, ataxia, decreased motor activity, a negative tail and toe pinch reflex and a slow righting reflex; periocular wetness and decreased motor activit
- Body weight:
- No effects on body weight gains were observed by 14 days postexposure
- Gross pathology:
- red lungs, dark livers, gas-filled stomachs (no effects on sacrificed survivors)
- Other findings:
- not reported
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance with an LC50 of 5.1 mg/l/4h is harmful by inhalation under the conditions used .
- Executive summary:
Groups of 5 male and 5 female Hilltop-Wistar albino rats [HLA(WI)BR] were exposed for four hours to dynamically generated vapour of 2,4- pentanedione. Concentrations tested were 628, 919, 1231 and 1508 ppm (corres ponding to 2619; 3823; 5133 and 6288 mg/m³, respectively). Chamber concentrations concurrently analysed throughout each 4-hour exposure by GC. Postexposure period 14 d; body weight determined at 0, 7 an d 14 d postexposure. A static exposure was also performed for determination of LT50. Groups of 5 male and 5 female rats were exposed to 7732 and 6388 ppm (corresponding to 32242 and 26638 mg/m³) for 74 and 37 minutes (males) and 8374 and 7449 ppm (corresponding to 34920 and 31062 mg/m³ for 78 and 39 minutes (females).
Dynamic exposure: The results of these tests indicate that the 4 hour dynamic LC50 (95 % confidence limits) for 2,4-pentanedione (combined male and female) is 1224 (1063 to 1409) ppm (corresponding to 5.104 (4.432 - 5.876) mg/m³). LC50 determined for combined male and female rat. Deaths were observed with both male and female rats exposed to concentrations of 1508 and 1231 ppm (mortality 8/10 and 6/10, respectively). Deaths occurred mostly during exposure or within 24 hours respectively). Deaths occurred mostly during exposure or within 24 hours post-exposure (1 exception on day 3 in male rats in the 1508 ppm group). No mortalities were observed with rats exposed to dynamic concentrations of 919 or 628 ppm. Clinical signs observed in rats of the 1508 and 1231 ppm exposure groups included periocular, perinasal and perioral wetness and encrustation, forced respiration, distended abdomen, tremors, ataxia, decreased motor activity, a negative tail and toe pinch reflex and a slow righting reflex. The respiratory difficulties decreased motor activity and ataxia persisted in survivors through post-exposure day 2. No clinical signs were observed in survivors of the 1508 and 1231 ppm exposure groups on day 6 and 5, respectively. The only clinical signs in the 919 ppm group were periocular wetness and decreased motor activity in both sexes of rats during exposure. These rats appeared normal again on post-exposure day one. In the 628 ppm exposure group, no signs of toxicity were observable during or post-exposure. Body weights were observed for all exposure groups at 14 days post-exposure; necropsy of rats that died: red lungs, dark livers, gas-filled stomachs (no effects on sacrificed survivors). Static exposure: LT50 for male rats 52 min (average concentration 7060 ppm) and 55 min for female rats (average concentration 7912 ppm). All rats exposed to static saturated vapour died during exposure in approximately 76 minutes. No mortalities occurred for either sex at the exposure time of approximately 38 minutes. Clinical signs observed for all static exposure groups included periocular and perinasal wetness, forced respiration and hypoactivity during exposure. A negative toe and tail pinch reflex, and negative surface righting were observed in rats following the 38 minutes exposure. These animals appeared normal by post-exposure day one. No effects on body weight gains were observed by 14 days postexposure. No gross lesions were found in survivors at necropsy. Discoloured lungs andlivers were observed in rats dying during static exposure. The test substance with an LC50 of 5.1 mg/l/4h is harmful by inhalation under the conditions used .
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