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Diss Factsheets
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EC number: 700-455-1 | CAS number: 380843-75-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 August 2009-15 October 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Draft Proposal for a New Guideline: In Vitro Skin Irritation: Reconstructed Human Epidermis (RhE) Test Method.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: European Community (EC). Commission regulation (EC) No. 761/2009, Part B: Methods for the Determination of Toxicity and other health effects, Guideline B.46 “In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test ". Official Journal of the Eur
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
- EC Number:
- 700-455-1
- Cas Number:
- 380843-75-4
- Molecular formula:
- C26H29Cl2N5O3
- IUPAC Name:
- 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
- Details on test material:
- Test substance preparation
Skin tissue was moistened with 5 μl of Milli-Q water (Millipore Corp., Bedford, Mass., USA) to ensure close contact to the tissue and 10 mg of the solid test substance was applied directly on top of the skin tissue. WAY-173606 (crystallized) was spread to match the size of the tissue.
Reference substances
Negative control: Phosphate buffered saline (PBS, Invitrogen Corporation, Breda, The Netherlands).
Positive control: 5% (aq) Sodium dodecyl sulphate (SDS, Sigma Aldrich, Zwijndrecht, The Netherlands) [CAS Number 151-21-3].
Constituent 1
Test animals
- Species:
- other: Not applicable
- Strain:
- other: Not applicable
Test system
- Type of coverage:
- other: Not applicable
- Preparation of test site:
- other: Not applicable
- Vehicle:
- water
- Controls:
- other: Not applicable
- Duration of treatment / exposure:
- 15 minutes treatment and 42 hours of post incubation
- Observation period:
- Observations/measurements in the study were recorded electronically using the following programme(s):
REES Centron Environmental Monitoring system version SQL 2.0 (REES Scientific, Trenton, NJ, USA): Temperature and humidity.
Multiskan spectrum version 1.00 (Thermo labsystems, Breda, The Netherlands) for optical density measurement. - Number of animals:
- three individual tissues
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: In vitro skin irritation test
- Value:
- > 50
- Remarks on result:
- other:
- Remarks:
- Basis: mean tissue viability. Time point: after 15 minutes treatment. Remarks: Since the mean relative tissue viability for WAY-173606 (crystallized) was above 50% WAY-173606 (crystallized) is considered to be non-irritant.. (migrated information)
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information in the in vitro skin irritation test Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Finally, it is concluded that this test is valid and that WAY-173606 (crystallized) is non-irritant in the in vitro skin irritation test under the
experimental conditions described in this report.
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