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Diss Factsheets
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EC number: 233-046-7 | CAS number: 10025-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Summary reported in limited detail, but sufficient for classification
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative toxicity of the chloride compounds of phosphorus (POCl3, PCl3, PCl5) in single and repeated exposures.
- Author:
- Molodkina NN
- Year:
- 1 974
- Bibliographic source:
- Toksikologiya Novykh Promyshlennykh Khimichesrikh Veshchestv, 13, 107-114
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A single dose was administered into the conjunctival sac.
- GLP compliance:
- no
Test material
- Reference substance name:
- Phosphoryl trichloride
- EC Number:
- 233-046-7
- EC Name:
- Phosphoryl trichloride
- Cas Number:
- 10025-87-3
- Molecular formula:
- Cl3OP
- IUPAC Name:
- phosphoroyl trichloride
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No additional information
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No information given
- Duration of treatment / exposure:
- No information given
- Observation period (in vivo):
- None specified
- Number of animals or in vitro replicates:
- No information given
- Details on study design:
- A single installation of phosphoryl trichloride was added into the conjunctional sac of the rabbit eye.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: not reported due to the severity of the reactions
- Basis:
- mean
- Time point:
- other: all
- Score:
- 100
- Max. score:
- 100
- Reversibility:
- not reversible
- Remarks on result:
- other: Theoretical maximum scores. Actual scores are not reported due to irreversible corrosion and necrosis.
- Irritant / corrosive response data:
- Limited information given in study report, but it was observed that an irreversible necrotic process developed which led to loss of vision
- Other effects:
- Corrosive effects were seen under the conditions of this study
Any other information on results incl. tables
An irreversible necrotic process was observed, that developed and led to a loss of vision
Applicant's summary and conclusion
- Interpretation of results:
- other: corrosive
- Conclusions:
- Severe corrosive effects were seen under the conditions of this study.
- Executive summary:
Severe corrosive effects were seen under the conditions of this study. Exposure to phosphoryl trichloride caused an irreversible necrotic process which resulted to the loss of vision.
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