Registration Dossier
Registration Dossier
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EC number: 203-401-0 | CAS number: 106-47-8
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original report not available (data from IPCS-INCHEM 48, 2003)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chloroaniline
- EC Number:
- 203-401-0
- EC Name:
- 4-chloroaniline
- Cas Number:
- 106-47-8
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 4-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report): p-chloroaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD rat
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 12, 53, 120 mg/m³
Basis:
nominal conc.
- No. of animals per sex per dose:
- 16
- Control animals:
- yes
Results and discussion
Results of examinations
- Details on results:
- From 12 mg/m3: haematology: red blood cell count decreased and methaemoglobin increased both reversible; histology: spleen: extramedullary haematopoiesis, haemosiderosis
From 53 mg/m3: mild to moderate cyanosis
From 120 mg/m3: body weight; rattling noise on breathing; irreversible clouding of the cornea and alopecia (no further information available from review, for example, on type of exposure)
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 12 mg/m³ air
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
