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EC number: 237-081-9 | CAS number: 13601-19-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- other: reviews from authorities
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Reviews so no primary information, however prepared by recognised authorities, Scientific Committees and WHO.
Data source
Referenceopen allclose all
- Reference Type:
- other: Toxicological evaluation by WHO
- Title:
- Toxicological evaluation of some food colours, emulsifiers, stabilizers, anti-caking agents and certain other substances
- Author:
- WHO
- Year:
- 1 969
- Bibliographic source:
- FAO Nutrition Meetings Report Series, No. 46A WHO/FOOD ADD/70.36, IPCS WHO
- Reference Type:
- other: Toxicological evaluation by WHO
- Title:
- Toxicological evaluation of some food colours, enzymes, flavour enhancers, thickening agents, and certain food additives
- Author:
- WHO
- Year:
- 1 975
- Bibliographic source:
- WHO Food Additives Series 6, IPCS WHO
- Reference Type:
- other: Scientific Committee Opinion
- Title:
- Opinion of the Scientific Committee for Animal Nutrition on the safety of Potassium- and Sodium Ferrocyanide used as anticaking agents
- Author:
- EU Health & Consumer Protection Directorate-General
- Year:
- 2 001
- Bibliographic source:
- OJ EC no. L248
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetrasodium hexacyanoferrate
- EC Number:
- 237-081-9
- EC Name:
- Tetrasodium hexacyanoferrate
- Cas Number:
- 13601-19-9
- Molecular formula:
- C6FeN6.4Na
- IUPAC Name:
- tetrasodium hexamethanuidimidoylironbis(ylium)
Constituent 1
Results and discussion
Any other information on results incl. tables
The 1969 WHO report was updated in 1975:
In an acute oral toxicity study in rats, the LD50 was 1600 -3200 mg/kg bw (1958).
Groups of 10 male and 10 female rats were maintained for 13 weeks on diets containing 0, 0.05, 0.5 and 5.0% sodium ferrocyanide. Growth rate and food consumption
was normal except at the 5% level, where there was slight depression. Haematocrit and haemoglobin values were depressed at the 5% level. Kidney weight of
both males and females at the 5% level and females at the 0.5% level was increased as were male adrenal and female pituitary gland weights in the 5% group.
The kidneys of rats at the 0.5% level showed a minimal degree of tubular damage. The effect was more marked at the 5% level, in addition granular and calcified
deposits were observed (Oser, 1959).
Human studies have demonstrated that i.v. injected ferrocyanide is excreted by glomerular filtration. Some tubular reabsorption occurs in man but not in dogs.
High levels were nephrotoxic in the short-term study in rats, but studies in dogs and man showed no adverse effects. No long-term studies are available (Remark of registrant: there are studies available currently).
Level causing no toxicological effect
Rat: 0.05% (= 500 ppm) in the diet equivalent to 25 mg/kg bw Estimate of acceptable daily intake for man: 0 -0.025 mg/kg bw
Estimate of acceptabve demonstrated that i.v. injected ferrocyanide is excreted by glomerular filtration. Some tubular
reabsorption occurs in man but not in dogs. High levels were nephrotoxic in the short-term study in rats, but studies in
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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