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EC number: 203-213-9 | CAS number: 104-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Fumigant Toxic Activity and Reproductive Inhibition Induced By Monoterpenes on Acanthoscelides obtectus (Say) (Coleoptera), a Bruchid of Kidney Bean (Phaseolus vulgaris L.)
- Author:
- CATHERINE REGNAULT-ROGER and ABDELAZIZ HAMRAOUI
- Year:
- 1 995
- Bibliographic source:
- J. srored Prod. Res. Vol. 31, No. 4, pp. 291-299, 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Principle mentioned below
- Principles of method if other than guideline:
- Combined Repeated, repro and developmental toxicity study of Cinnamaldehyde in 1 generation of A. Obtectus insects.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Cinnamaldehyde
- EC Number:
- 203-213-9
- EC Name:
- Cinnamaldehyde
- Cas Number:
- 104-55-2
- Molecular formula:
- C9H8O
- IUPAC Name:
- 3-phenylacrylaldehyde
- Details on test material:
- - Name of test material (as cited in study report): Cinnamaldehyde
- Molecular formula (if other than submission substance): C9-H8-O
- Molecular weight (if other than submission substance): 132.1612 g/mole
- Substance type: Organic
- Physical state: Liquid
- Impurities (identity and concentrations): No data avaialbe
Constituent 1
Test animals
- Species:
- other: Insect
- Strain:
- other: Acanthoscelides obtectus (Coleoptera)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: Cultivated own Institute.
- Age at study initiation: (P) x wks; (F1) x wks :No data avaialbe
- Weight at study initiation: (P) Males: x-x g; Females: x-x g; (F1) Males: x-x g; Females: x-x g: No data avaialbe
- Fasting period before study: No data avaialbe
- Housing: No data avaialbe
- Diet (e.g. ad libitum): No data avaialbe
- Water (e.g. ad libitum): No data avaialbe
- Acclimation period: No data avaialbe
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 27°C
- Humidity (%):65-75%
- Air changes (per hr): No data avaialbe
- Photoperiod (hrs dark / hrs light): 12 h light/l2 h dark
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- not specified
- Details on exposure:
- At the end of21 days, all adults were removed from the experimental chambers. Hatching larvae penetrated the seeds to continue development and the experiment was continued until the last emergence of the adults’ Fl progeny (about a 35-45 day period).
Mating procedure
- M/F ratio per cage: 1 : 1 ratio
- Length of cohabitation: 6 hours
- Proof of pregnancy: [vaginal plug / sperm in vaginal smear] referred to as [day 0 / day 1] of pregnancy No data available
- After ... days of unsuccessful pairing replacement of first male by another male with proven fertility. No data available
- Further matings after two unsuccessful attempts: [no / yes (explain)] No data available
- After successful mating each pregnant female was caged (how): No data available
Any other deviations from standard protocol:
Adult males and females were separated on the first day of emergence. The following day (24 h), pairs of beetles was set up and observed during the following 6 h. At the end of this time, only pairs known to have mated were chosen. Each treatment included 10 pairs (1 male and 1 fertilized female). Each pair was enclosed in an experimental chamber with six kidney beans and the small fumigant vessel prepared with chemicals. - Duration of treatment / exposure:
- 35-45 day period
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1.5 x 10-6 and 6 x 10-6 M (0, 0.0001989 and 0.0007929 mg/m3)
Basis:
no data
- No. of animals per sex per dose:
- Total: 60 insects
0 M: 10 males, 10 females
1.5 x 10-6 M: 10 males, 10 females
6 x 10-6 M: 10 males, 10 females - Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 0.001 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
Applicant's summary and conclusion
- Conclusions:
- NOAEL was considered to be 0.0007929 mg/m3 when Acanthoscelides obtectus (Coleoptera) male and female insects treated with Cinnamaldehyde
- Executive summary:
In a combined repeated and repro-development toxicity study,male and femaleAcanthoscelides obtectus (Coleoptera)insects were treated by inhalation withCinnamaldehydein the concentration of 0, 1.5 x 10-6M or 6 x 10-6M in an experimental chamber. All insects were observed for female fecundity, oviposition and the development of neonate and intracotyledonal larvae. No effect were observed on life span of adults, fecundity of female insects and oviposition of eggs as compared to control. In addition, no effect were observed on development of larvaes, larval penetration and adult emergence of treated insects as compared to control. Therefore, NOAEL was considered to be 6 x 10-6M whenmale and female Acanthoscelides obtectus (Coleoptera)insects were treated with Cinnamaldehydeby inhalation during a 35-45 day period.
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