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Diss Factsheets
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EC number: 215-676-4 | CAS number: 1341-49-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Single epidemiological study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Epidemiologic health study of workers in an aluminium smelter in Kitimat, B.C. II effects on musculoskeletal and other systems.
- Author:
- Chan-Yueng et al
- Year:
- 1 983
- Bibliographic source:
- Arch. Environ. Hlth.; 38: 34-40.
Materials and methods
- Study type:
- cohort study (prospective)
- Endpoint addressed:
- repeated dose toxicity: inhalation
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Investigation of health effects in workers in an aluminium smelter.
- GLP compliance:
- no
Test material
- Reference substance name:
- Hydrogen fluoride
- EC Number:
- 231-634-8
- EC Name:
- Hydrogen fluoride
- Cas Number:
- 7664-39-3
- IUPAC Name:
- fluoride
- Details on test material:
- Exposure to particulate and gaseous fluoride was assessed.
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Details on study design:
- The health effects in 2066 workers in an aluminium smelter was studied. The cohort comprised of high and medium exposed potroom workers as well as low exposed controls and a miscellaneous group. For each group exposure to particulate and gaseous fluoride, the urinary fluoride excretion were determined.
- Exposure assessment:
- measured
- Details on exposure:
- The cohort comprised of high and medium exposed potroom workers as well as low exposed controls and a miscellaneous group.
- Statistical methods:
- Not relevant.
Results and discussion
- Results:
- No overt signs of skeletal fluorosis were observed in workers exposed to concentrations of up to 0.48 mg F/m3. (0.2 mg/m3 for gaseous F- and 0.28 mg/m3 for fluoride dust) for up to ten years. Monitoring of the blood biochemistry parameters did not indicate any occurence of hepatic or renal effects. Changes in haemoglobin and haematocrit and calcium, although significant, were within the normal biological range. Serum calcium but not phosphate was increased in the highest exposure group. It was concluded that no overt signs of skeletal fluorosis or renal, hepatic or haematological effects were obsevred in workers exposed to 0.48 mg (total) fluoride /m3 for up to ten years.
- Confounding factors:
- Not relevant
Any other information on results incl. tables
The number of workers in each group and the levels of exposure are presented in the table below;
Group |
Number exposed |
Average total airbourne fluoride (mg/m3) |
Average gaseous fluoride (mg/m3) |
Average particulate fluoride (mg/m3) |
controls |
880 |
0.053 |
0.015 |
0.038 |
potroom/high |
570 |
0.48 |
0.20 |
0.28 |
potroom/medium |
332 |
0.12 |
0.057 |
0.062 |
miscellaneous |
284 |
0.46 |
0.054 |
0.41 |
Applicant's summary and conclusion
- Conclusions:
- No overt signs of skeletal fluorosis or renal, hepatic or haematological effects were observed in workers exposed up to 0.48 mg F/m3. (0.2 mg/m3 for gaseous F- and 0.28 mg/m3 for fluoride dust) for up to ten years.
- Executive summary:
No overt signs of skeletal fluorosis were observed in workers exposed up to 0.48 mg F/m3. (0.2 mg/m3 for gaseous F- and 0.28 mg/m3 for fluoride dust) for up to ten years. Monitoring of the blood biochemistry parameters did not indicate any occurence of hepatic or renal effects. Changes in haemoglobin and haematocrit and calcium, although significant, were within the normal biological range. Serum calcium but not phosphate was increased in the highest exposure group. It was concluded that no overt signs of skeletal fluorosis or renal, hepatic or haematological effects were obsevred in workers exposed to 0.48 mg (total) fluoride /m3 for up to ten years.
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