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EC number: 700-102-1 | CAS number: 105112-76-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The test on ready biodegradability was carried out in accordance with the Japanese guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: This study was conducted as a "biodegradation study of chemicals due to microorganisms" (Kanpogyo Notification No. 5, Yakuhatsu Notificatin No. 615, and 49 Kikyoku Notification No. 392).
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-{[4'-(3-aminophenoxy)-[1,1'-biphenyl]-4-yl]oxy}aniline
- EC Number:
- 700-102-1
- Cas Number:
- 105112-76-3
- Molecular formula:
- C24H20N2O2
- IUPAC Name:
- 3-{[4'-(3-aminophenoxy)-[1,1'-biphenyl]-4-yl]oxy}aniline
- Details on test material:
- - Name of test material (as cited in study report): 4,4'-bis(4-aminophenoxy)biphenyl
- Molecular weight (if other than submission substance): 368.44
- Physical state: White powder
- Analytical purity: 99.98 %
- Lot/batch No.: 89-42001
- Stability under test conditions: IR absorption spectra determined at the beginning and end of the study were compared. The two spectra obtained were completely identical and no difference was noted, indicating that the test substance remained stable during the study period.
- Storage condition of test material: Protected from light at room temperature
Constituent 1
Study design
- Oxygen conditions:
- not specified
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Active sludge, purchased from the Chemical Evaluation and Research Institute, Japan on 17 April 1997, was incubated before using in the study.
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Remarks:
- Substance quantitated by HPLC
- Details on study design:
- The test substance concentration was 100 mg/L. The standard activated sludge concentration was 30 mg/L. Temperature was 25 +/- 1 °C. The study was conducted during a time period of 28 days. The concentration of activated sludge suspension purchased was 3970 mg/L. An amount of 2.27 mL was added to each bottle. Test fluids were prepared using 6 culture bottles with 3 containing test substance and sludge, one aniline, one test substance and water, and one water. Culture bottles were observed everyday except holidays to determine the growth of activated sludge and the presence or absence of coloration. Degradation of aniline was determined 1 and 2 weeks after starting incubation in order to determine the activity of activated sludge.
Reference substance
- Reference substance:
- aniline
Results and discussion
- Preliminary study:
- No oxygen consumption associated with the degradation of the test substance was observed throughout the incubation period. This finding indicates that no oxidative microbiological degradation occurred. No microbial growth was noted during the incubation period.
No microbial growth was noted in any of the 3 test substance + sludge groups at the end of the study. pH was almost neutral at the end of the incubation period.
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 1.63
- St. dev.:
- 1.39
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- Aniline showed high percent degradations of 45.9 % and 68.7 %, respectively, in 7 and 14 days, satisfying the criteria for the present study and showing its efficacy.
Any other information on results incl. tables
Table 1: Results of the degradability test with the test substance
Test no. |
Test conditions |
Injected amount of substance (mg) |
TOD (mg) |
BOD (mg) |
Degradability (%) |
||||
7 days |
14 days |
28 days |
7 days |
14 days |
28 days |
||||
1 |
Test material + activated sludge, Bottle 1 |
32.1 |
83.8 |
1.0 |
2.2 |
3.4 |
0.0 |
0.0 |
0.0 |
2 |
Test material + activated sludge, Bottle 2 |
30.2 |
78.8 |
1.0 |
2.1 |
3.5 |
0.0 |
0.0 |
0.0 |
3 |
Test material + activated sludge, Bottle 3 |
30.2 |
78.8 |
1.2 |
2.5 |
4.1 |
0.2 |
0.0 |
0.0 |
4 |
Water + activated sludge (control blank) |
0.00 |
0.0 |
1.0 |
2.5 |
4.2 |
0.0 |
0.0 |
0.0 |
5 |
Aniline + activated sludge |
30.0 |
90.3 |
42.5 |
64.5 |
67.5 |
45.9 |
68.7 |
70.1 |
6 |
Test material + water |
29.9 |
78.0 |
0.0 |
0.0 |
0.0 |
- |
- |
- |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- according to results obtained with reference substance
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Results of analysis by the BOD method and the direct method (HPLC) showed that the test substance was hardly degraded, suggesting that it is unlikely to be biodegraded under the conditions of the present study.
- Executive summary:
The ready biodegradability of the substance 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline has been tested in a 28-day study in accordance with the Japanese guidelines (Inaba and Matsue 1997) using activated sludge and a test concentration of 100 mg/L, which was achieved by dissolving the test substance in an organic solvent before dissolving it in water. The biodegradation was estimated on the basis of the biological oxygen demand (BOD) and by direct analysis of the test material using high-performance liquid chromatography (HPLC). The BOD did not indicate any degradation of the test substance; no relevant loss of test substance over the study period of 28 days was found with the HPLC analysis and the study indicated that 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline was not readily biodegradable.
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