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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
500 mg dimethyl propylphosphonate were semiocclusively applied once to the intact skin of 3 female adult New Zealand White rabbit (3-4 kg) for an exposure period of 24 hours. Evaluation of skin irritation was made until day 14 according to DRAIZE.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl propylphosphonate
EC Number:
242-555-3
EC Name:
Dimethyl propylphosphonate
Cas Number:
18755-43-6
Molecular formula:
C5H13O3P
IUPAC Name:
dimethyl propylphosphonate
Test material form:
other: clear colourless liquid
Details on test material:
- Purity: 98.7 %

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
4 hours
Observation period:
14 days
Number of animals:
3 animals

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
1
Max. score:
1
Reversibility:
not fully reversible within: 14d
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
1
Max. score:
1
Reversibility:
fully reversible within: 7d
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0 - 1
Max. score:
1
Reversibility:
fully reversible within: 24h
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48, and 72 hours
Score:
0.66
Max. score:
4
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: erythema was fully reversible in 2 of 3 animals
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Max. score:
0
Remarks on result:
other: No edema was seen at any animal at any time point (1h - 14d) after 4 h of exposure
Other effects:
no other effects found

Any other information on results incl. tables

Dimethyl propylphosphonate was 'slightly irritating to the skin' (exposure period: 4 hrs).

Very slight, barely perceptible erythematous reactions were observed in all three animals. In one animal signs were evident only 1 hour post administration and in the other animals up to and at 72 hours and 14 days, respectively.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

Dimethyl propylphosphonate (500 mg) was semiocclusively applied once to the intact skin of 3 female adult New Zealand White rabbit (3-4 kg) for an exposure period of 4 hours. Evaluation of skin irritation was made until day 14 according to Draize.

Dimethyl propylphosphonate was 'slightly irritating to the skin' (exposure period: 4 hrs).

Very slight, barely perceptible erythematous reactions were observed in all three animals. In one animal signs were evident only 1 hour post administration and in the other animals up to and at 72 hours and 14 days, respectively. Erythema score = 0.66, edema score = 0.

Therefore a classification is not justified.