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EC number: 221-435-4 | CAS number: 3091-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 26, 1982 - June 14, 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Trichlorooctylstannane
- EC Number:
- 221-435-4
- EC Name:
- Trichlorooctylstannane
- Cas Number:
- 3091-25-6
- Molecular formula:
- C8H17Cl3Sn
- IUPAC Name:
- trichlorooctylstannane
- Details on test material:
- TK 11386, Monooctyltin Trichloride [CAS No. 3091-25-6]; liquid, purity not reported, source: CIBA-GEIGY, Ltd.; code no. TK 11386; batch no. D 18-671.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif:RAIf (SPF), F3-crosses of RII 1/Tif x RII 2/Tif
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Initial body weight range: 180 - 212 g
Initial age: 7 - 8 weeks
Individual identification: By colour code using picric acid
Husbandry: The animals were kept under conventional laboratory conditions. They were caged in groups of 5 in Macrolon cages type 3 with soft wood bedding.
The animal room was kept at a temperature of 22 ± 3 deg C, relative humidity 55 ± 15%, 12 hours light/day cycle, and approx. 15 air changes/hour.
The animals were given rat food, NAFAG no. 890, NAFAG AG, Gossau, Switzerland, and water ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- Groups of 10 rats (5 males/5 females) were exposed to three nominal dose levels: 1000, 2500, and 5000 mg/kg bw. A single dose of the test substance was delivered by oral gavage, as a solution in arachid oil (in a volume of 10 mL/kg). Rats were fasted overnight prior to dosing. Following dosage, rats were provided commercial feed (NAFAG No. 890) and water ad libitum.
- Doses:
- 1000, 2500, and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 rats/sex/dose
Total 30 animals - Control animals:
- no
- Details on study design:
- Animals were observed once daily for signs and symptoms of systemic toxicity, and twice daily (a.m. and p.m.) for mortality over the 14-day observation period. Animals were necropsied following death or at the end of the observation period. Animals were weighed on days 1, 7, 14 and at death. At the end of the 14-day observation period, surviving rats were weighed prior to being sacrificed.
- Statistics:
- Group means and SD were calculated from the body weights.
LD50 and the 95% confidence limits were computed by the logit method (Berkson, 1944).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 080 mg/kg bw
- 95% CL:
- >= 2 176 - <= 5 404
- Remarks on result:
- other: Data for males and females were combined.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 080 mg/kg bw
- 95% CL:
- >= 1 870 - <= 9 307
- Remarks on result:
- other: males only
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 080 mg/kg bw
- 95% CL:
- >= 1 870 - <= 9 307
- Remarks on result:
- other: females only
- Mortality:
- MORTALITY (number of deaths/number of animals tested):
1000 mg/kg bw: Males, 0/5; Females, 0/5
2500 mg/kg bw: Males, 0/5; Females, 0/5
5000 mg/kg bw: Males, 5/5; Females, 5/5
Animals died between 5 and 24 hours post dosing. - Clinical signs:
- other: Signs of systemic toxicity were observed at all dose levels, with the most pronounced signs of toxicity occurring at the 5000 mg/kg level. Signs of toxicity included sedation, dyspnoea, exophthalmus, ruffled fur, curved body position, and mortality.
- Gross pathology:
- No compound-related gross organ changes were observed at the low dose levels. At the 5000 mg/kg level, the compound was extremely corrosive. The stomachs of all the rats were extended and the stomach walls showed extensive hemorrhages with membranous desquamation of the pyloric part. In many animals, the stomach was perforated and the surface of livers and kidneys getting into contact with the stomach contents were also corroded.
Any other information on results incl. tables
RS-Freetext:
MORTALITY (number of deaths/number of animals tested):
1000 mg/kg bw: Males, 0/5; Females, 0/5
2500 mg/kg bw: Males, 0/5; Females, 0/5
5000 mg/kg bw: Males, 5/5; Females, 5/5
Animals died between 5 and 24 hours after dosing.
Mean body weight of males and females increased during testing of dose levels of 1000 and 2500 mg/kg. Signs of systemic toxicity were observed at all dose levels, with the most pronounced signs of toxicity occurring at the 5000 mg/kg level. Signs of toxicity included sedation, dyspnoea, exophthalmus, ruffled fur, curved body position and mortality.
Gross organ changes in the 5000 mg/kg dose level test subjects consisted of extended stomachs with the stomach walls showing extensive hemorrhages, with membranatious desquamation of the pyloric part. Several animals also exhibited a perforated stomach while the surface of the liver and kindeys were corroded where they contacted the stomach. No gross organ changes were found in the lower dose groups.
The LD50 and 95% Confidence Limits were calculated using the logit method (Berkson, 1944):
LD50 (males)= 3080 mg/kg bw (95% CL = 1870-9307 mg/kg bw)
LD50 (females)= 3080 mg/kg bw (95% CL = 1870-9307 mg/kg bw)
LD50 (both sexes)= 3080 mg/kg bw (95% CL = 2176-5404 mg/kg bw)
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: company standard: LD50 500-5000 mg/kg (slight acute toxicity)
- Conclusions:
- The acute oral LD50 of monooctyltin trichloride in the rat is 3080 (95% confidence limits: 2176-5404) mg/kg bw.
- Executive summary:
The acute oral LD50 of monooctyltin trichloride was investigated in rats. Study adhered to OECD Guideline No. 401. Animals (5 rats/sex/dose) were administered a single dose of the test material dissolved in arachis oil by gavage at a volume of 10 mL/kg. Three doses were used: 1000, 2500, and 5000 mg/kg bw. This was followed by an observation period for 14 days or up to the disappearance of symptoms. Mortality, clinical signs and symptoms, and body weights were recorded. Necropsies were performed immediately after death or at the end of the observation period. LD50 was calculated by the logit method.
All 5 males and 5 females in the high dose group died between 5 and 24 hours after dosing. Signs of systemic toxicity were observed at all dose levels, with the most pronounced signs of toxicity occurring at the 5000 mg/kg level. Signs of toxicity included sedation, dyspnoea, exophthalmus, ruffled fur, curved body position, and mortality.
Mean body weight of males and females increased during the observation period with dose levels of 1000 and 2500 mg/kg. None of the animals in the high-dose group survived beyond the 24 hours of exposure.
No compound-related gross organ changes were observed at the low dose levels. At the 5000 mg/kg level, the compound was extremely corrosive. The stomachs of all the rats were extended and the stomach walls showed extensive hemorrhages with membranous desquamation of the pyloric part. In many animals, the stomach was perforated and the surface of livers and kidneys getting into contact with the stomach contents were also corroded.
The acute oral LD50 of monooctyltin trichloride in the rat was calculated as 3080 (95% confidence limits: 2176-5404) mg/kg bw. According to the company standard, this chemical was categorised as having slight acute toxicity.
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