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EC number: 248-697-2 | CAS number: 27858-32-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 11, 1978 - April 28, 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The test procedure is not based on guideline, but it is comparable with OECD Guideline 401. Though the detailed description of method and the discussion of the result is missing, the study was performed in consistent way and it is scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- The study report do not include details on test procedure and test substance. Only male rats were used in the study.
- Principles of method if other than guideline:
- LD50 test; 4 groups of ten male rats received a single oral gavage of the test substance. Survivors were sacrificed 14 days later. LD50 value was calculated from the mortality data using the method of D.J. Finney. Probit analysis, 2nd Ed., 1952, Cambridge University Press.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(ethyl acetoacetato-O1',O3)bis(propan-2-olato)titanium
- EC Number:
- 248-697-2
- EC Name:
- Bis(ethyl acetoacetato-O1',O3)bis(propan-2-olato)titanium
- Cas Number:
- 27858-32-8
- Molecular formula:
- C18H32O8Ti
- IUPAC Name:
- Bis(ethylacetoacetato‐O1',O3")bis(propan‐2‐olato)titanium
- Details on test material:
- - Name of test material (as cited in study report): Titanic acid, diacetoacetyl-diisopropyl; Haskell number 11,939
- Lot/batch No.: Tyzor DC MPD 4809, Product code 976070 Lot #1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Chr:CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No details on test animals and environmental conditions available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
no vehicle was used
MAXIMUM DOSE VOLUME APPLIED:
Dose (mg/kg) Average dose (ml)
29 000 6,52
25 000 5,58
20 000 4,68
17 000 3,96
DOSAGE PREPARATION (if unusual): Test material was administered, as received, without any preparation - Doses:
- 17 000, 20 000, 25 000, 29 000 mg/bw
- No. of animals per sex per dose:
- 10 males / dose
- Control animals:
- no
- Details on study design:
- The test material, as received, was administered by intragastric intubation to four groups of ten young adult male rats in single dose.
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:Animals were weighed at the initiation of the study
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs and body weight
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 23 020 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Dose (mg/kg) Mortality ratio
29 000 10/10
25 000 5/10
20 000 1/10
17 000 2/10 - Clinical signs:
- other: Dose (mg/kg) Clinical signs 29 000 Ataxia, lethargy, rapid and labored respiration, gasping, prostration, salivation, lacriation, stained mouth and weight loss after dosing at 29 000 mg/kg 25 000 Ataxia, lethargy, belly-to-cage posture, rapid and labo
- Gross pathology:
- not done
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Acute toxicity of bis(ethyl acetoacetato-O1',O3)bis(propan-2-olato)titanium was determined by using test method equal to OECD 401. LD50 value was 23 020mg/kg of body weight measured by administering test substance as a single oral dose to male rats.
- Executive summary:
This study was regarded reliable with restrictions since only male rats were used in this study. Furthermore, the study report does not contain all details of test animals and the study do not include all details on test substance, test method and results. However, the study was performed in a consistent way and it is scientifically acceptable.
In this study, Bis(ethyl acetoacetato-O1',O3)bis(propan-2 -olato)titanium was administered as a single oral dose by intragastric intubation to male rats. Clinical signs of toxicity were observed in all dosed animals. Under the conditions of this test, the LD50 was 23 020 mg/kg of body weight. By the study report this substance is considered to have very low toxicity.
The result of this study would lead to no classification for acute oral toxicity according to EU Regulation No. 1272/2008 (CLP).
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