Aluminium nitrate

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: Published review

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The US ATSDR Toxicological Profile for Aluminium contains a comprehensive and authoritative review of the toxicokinetic properties of aluminium in various forms

Data source

Reference

Reference Type:

review article or handbook

Title:

Toxicological Profile for Aluminium

Author:

ATSDR

Year:

2008

Bibliographic source:

U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry

Materials and methods

Objective of study:

toxicokinetics

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Review of the toxicokietics of various forms of aluminium based on available literature data

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

various forms of aluminium

IUPAC Name:

various forms of aluminium

Test animals

Species:

other: not applicable

Administration / exposure

Route of administration:

other: not applicable

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:

The bioavailability of aluminium is strongly influenced by the aluminium compound and also by the presence of dietary constituents which can complex with aluminium and thereby enhance or inhibit its absorption. The main mechanism of absorption is passive diffusion through paracellular pathways.

Details on distribution in tissues:

Aluminium binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues.

Details on excretion:

Absorbed aluminium is excreted principally in the urine and, to a lesser extent, in the bile.

Metabolite characterisation studies

Metabolites identified:

not measured

Details on metabolites:

Not applicable

Bioaccessibility (or Bioavailability)

Bioaccessibility (or Bioavailability) testing results:

Not considered

Any other information on results incl. tables

This review concludes that aluminium is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. Approximately 0.1-0.6% of ingested aluminium is usually absorbed,

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
This review concludes that aluminium is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. Approximately 0.1-0.6% of ingested aluminium is usually absorbed.

Executive summary:

This review concludes that aluminium is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. Approximately 0.1-0.6% of ingested aluminium is usually absorbed, although the gastrointestinal absorption of some forms of aluminium may be lower. Unabsorbed aluminium is excreted in the faeces. The bioavailability of aluminium is strongly influenced by the aluminium compound and also by the presence of dietary constituents which can complex with aluminium and thereby enhance or inhibit its absorption. The main mechanism of absorption is passive diffusion through paracellular pathways. Aluminium binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. Absorbed aluminium is excreted principally in the urine and, to a lesser extent, in the bile.