Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 401-990-0 | CAS number: 106990-43-6 CHIMASSORB 119; LOWILITE 19
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD 222 guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 222 (Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei))
- Principles of method if other than guideline:
- In all treatments tested the soil moisture was more than 10% higher at the end of the test than the initial moisture (12.7% to 32.9%) as recommended by the guideline (100 ± 10% of the original moisture). These deviations are considered to have had no impact on the outcome and validity of this study.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
- EC Number:
- 401-990-0
- EC Name:
- N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine
- Cas Number:
- 106990-43-6
- Molecular formula:
- C132 H250 N32
- IUPAC Name:
- N2-[2-({4,6-bis[butyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl}[3-({4,6-bis[butyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl}amino)propyl]amino)ethyl]-N2-[3-({4,6-bis[butyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl}amino)propyl]-N4,N6-dibutyl-N4,N6-bis(1,2,2,6,6-pentamethylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- no
- Details on preparation and application of test substrate:
- Method of mixing into soil (if used):
The test item was poorly soluble in water; therefore, mixtures of finely ground quartz sand and the test item were produced for the test item concentrations.
The test item was mixed in an amount of quartz sand (2% of the quartz sand from the total amount of the artificial soil had been separated) to prepare each test item concentration, respectively. The test item was incorporated into the remainder of the artificial soil by thoroughly mixing in the respective test item/quartz sand mixtures for 5 minutes. The treated artificial soil was filled into the test vessels. Per test vessel an amount corresponding to 500 g dw (dry weight) was used.
- Controls: water treated
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Source: ECT Oekotoxikologie GmbH, since 1994 (originally delivered by Co. Landenberger)
- Age at test initiation (mean and range, SD): >= 2 months - <= 1year, (with clitellum)
- Weight at test initiation (mean and range, SD): 250mg - 600 mg (differnce between individuals not more than 4 weeks)
ACCLIMATION
- Acclimation period: >= 24h
- Acclimation conditions (same as test or not): artificial soil under test conditions
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 56 d
Test conditions
- Test temperature:
- 19-21.2°C
- pH:
- 5.7-6.5
- Moisture:
- soil moisture(day 0): 49.3 – 51.9% (rec. 40 – 60% of the WHCmax),
soil moisture (day 56): 57.5 – 65.5% (rec. deviation ≤ 10% from day 0) - Details on test conditions:
- TEST SYSTEM
- Test container (material, size): Bellaplast containers (Polarcup GmbH) of inert/non-toxic plastic (polystyrene), 170cm2 x 6 cm, covered with transparent lid
- Amount of soil or substrate: 500g dw
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 8
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Composition (if artificial substrate):
The composition of this artificial soil was based on OECD Guideline No. 222 (2004) (the percentages refer to the dry weight):
- 10% Sphagnum peat (no visible plant remains; finely ground and air-dried)
- 20% Kaolin-Clay (kaolinite content > 30%)
- 69.6% Quartz sand (fine sand content with particles between 50 and 200 μm higher than 50%)
- 0.4% Calcium carbonate (CaCO3)
The air dried peat was shredded in a chaff-cutter. Afterwards, all parts of the artificial soil were mixed homogeneously. The pH value was adjusted to 6 ± 0.5 using calcium carbonate. The moisture content was adjusted to 40-60% of WHCmax using deionised water. The water content of the test substrate was checked weekly by reweighing the test vessels and losses of water will be compensated.
OTHER TEST CONDITIONS
- Photoperiod/ Light intensity: light cycle: 16 : 8 h with a constant light intensity at the substrate of 442 - 583 lx (recommended 400 – 800 lx),
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- day 28 mortality and biomass
The adult worms were sampled out of the test containers after the feeding activity has been recorded for each test container. During this process morphological and behavioural changes and the number of surviving adult worms in each test container were recorded. Worms were classified as dead when they did not respond to a gentle mechanical stimulus to the front end. The combined weight of the surviving adult worms from each replicate was determined.
- day 56 reproduction
The adult worms were sampled out of the test containers after the feeding activity has been recorded for each test container. During this process morphological and behavioural changes and the number of surviving adult worms in each test container were recorded. Worms were classified as dead when they did not respond to a gentle mechanical stimulus to the front end. The combined weight of the surviving adult worms from each replicate was determined.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2
62.5 mg test item/kg soil (dw)
125 mg test item /kg soil (dw)
250 mg test item /kg soil (dw)
500 mg test item /kg soil (dw)
1000 mg test item /kg soil (dw) - Nominal and measured concentrations:
- 62.5, 125, 250, 500, 1000 mg test item/kg artificial soil (dw);
- Reference substance (positive control):
- yes
- Remarks:
- Carbendazim
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 28 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: biomass
- Duration:
- 28 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: biomass
- Duration:
- 56 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 56 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- Almost the whole food was consumed by the worms in all test vessels after 7, 14, 21 and 28 days of the application of the test item.
No other effects on behavior or morphology of the adult earthworms were observed.
Validity criteria:
mortality of the adults in the control = 0% (required: ≤ 10%);
mean number of juveniles in the control = 464.8 (required: ≥ 30)
CV for the number of juveniles in the control = 14.9 (required: ≤ 30%) - Results with reference substance (positive control):
- Carbendazim as the active ingredient of the fungicide Derosal was tested as the toxic reference item from August 14 – October 09, 2013 (ECT Study No.: IRR1308). It was used in concentrations of 0.32, 1 and 3.2 mg a.s./kg.
The NOECReproduction for Carbendazim tested as a reference item was determined as 0.32 mg/kg soil (dw) and accordingly the LOECReproduction was determined as 1.0 mg/kg soil (dw). These observed effects are within the range expected from the guideline (1-5 mg Carbendazim/kg soil (dw)) and hence acceptable sensitivity of the test system is assured. - Reported statistics and error estimates:
- (Dunnett’s t-test (2-sided, p ≤ 0.05), Dunnett’s t-test (1-sided, p ≤ 0.05);
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.