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EC number: 209-691-5 | CAS number: 590-86-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
Classification concerning carcinogenicity is not warranted.
Additional information
The carcinogenic potential of isobutyraldehyde was examined in two rodents studies.
A 2-year inhalation study was reported (NTP, 1999). In this study (done with NTP standards), male and female rats were given vapour concentrations of 500, 1000 and 2000 ppm (= 1.5, 3 and 6 mg/l). No increase in neoplasm incidences that could be attributed to exposure to isobutyraldehyde was observed in male or female rats. Non-neoplastic lesions related to isobutyraldehyde exposure were limited to the nose and consisted of squamous metaplasia of the respiratory epithelium, degeneration of the olfactory epithelium, and suppurative inflammation. Incidences of minimal to mild squamous metaplasia in 1000 and 2000 ppm males and females and in 500 ppm females were significantly greater than those in the chamber controls. Minimal to mild degeneration of the olfactory epithelium occurred in the 2000 ppm males and females. Incidences of suppurative inflammation (rhinitis) in both sexes exposed to 2000 ppm were increased compared to controls. The LOAEC was found to be 500 ppm.
Another 2-year inhalation study (NTP, 1999) using male and female mice showed also a negative result. Mice were given vapour concentrations of 500, 1000 and 2000 ppm (= 1.5, 3 and 6 mg/l). No neoplasms that could be attributed to isobutyraldehyde exposure were observed in either males or females. Non-neoplastic lesions related to isobutyraldehyde exposure were limited to the nose. The incidences of olfactory epithelial degeneration in 1000 and 2000 ppm males and females were significantly greater than in the chamber controls. The NOAEC was found to be 500 ppm. This study was done with NTP-standards.
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