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Diss Factsheets
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EC number: 700-729-0 | CAS number: 1369500-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a relevant guideline without deviations. It was not carried out according to GLP, but it was performed in a test facility which has been certified to be in compliance with the principles of GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- GLP compliant facility
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- Pow
- Partition coefficient:
- 170
- Temp.:
- 25 °C
- pH:
- >= 6.4 - <= 6.5
- Type:
- log Pow
- Partition coefficient:
- 2.2
- Temp.:
- 25 °C
- pH:
- >= 6.4 - <= 6.5
- Conclusions:
- The octanol / water partition coefficient ( Pow ) of CA4915 has been determined using the shakeflask method:
Pow = 170 (+/- 1.3) log Pow = 2.2 at 25 °C - Executive summary:
The partion between octanol and water was determined in 3 pairs of experiments using differeing concentrations of test substance. The results for each pair were in good agreement and hence the method is considered adequate and reliable.
Reference
Test mixture | P1 | P2 | P3 | P4 | P5 | P6 | |
Amount CA4915 (mg) | 15.0 | 15.1 | 29.9 | 30.2 | 7.44 | 7.56 | |
Corrected for purity (mg) | 14.7750 | 14.8735 | 29.4515 | 29.7470 | 7.3284 | 7.4466 | |
Volume of octanol (ml) | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | |
Volume of water (ml) | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | |
CA4915 in octanol phase 1 2Average | 723.182723.692723.437 | 736.017735.691735.854 | 728.076726.415727.246 | 714.116714.710714.413 | 691.007690.830690.919 | 733.157732.415732.786 | |
CA4915 in water phase 1 2Average | 4.2294.2084.219 | 4.2154.2014.208 | 4.1914.2084.200 | 4.0964.1074.102 | 3.9543.9463.950 | 4.2064.1884.197 | |
pH of aqueous phase | 6.48 | 6.46 | 6.43 | 6.49 | 6.46 | 6.44 | |
CA4915 amount in octanol phase (mg) | 14.4687 | 14.7171 | 29.0898 | 28.5765 | 6.9092 | 7.3279 | |
CA4915 amount in aqueous phase (mg) | 0.0844 | 0.0842 | 0.0840 | 0.0820 | 0.0079 | 0.0839 | |
CA4915 in both phases (mg) | 14.5531 | 14.8013 | 29.1738 | 28.6585 | 6.9882 | 7.4118 | |
Recovery (%) | 98.5 | 99.5 | 99.1 | 96.3 | 95.4 | 99.5 | |
Pow | 171.471 | 174.870 | 173.154 | 174.162 | 174.916 | 174.598 | |
Average Pow | 173.2 | 173.7 | 174.8 | ||||
Average Pow | 170 +/- 1.3 | ||||||
Average Log Pow | 2.2 |
The final results for the average Pow value, the standard deviation and the log Pow value (in bold) have been quoted correct to two significant figures.
Description of key information
Log Pow = 2.2 at 25 °C, OECD 107, shake flask method, Halarnakar 2011
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.2
- at the temperature of:
- 25 °C
Additional information
Only a single study conducted according to guidelines is available for this endpoint. The study is considered to be relevant, reliable (Klimisch 1) and adequate for the purposes of risk assessment, classification and labelling.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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