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Diss Factsheets
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EC number: 203-813-0 | CAS number: 110-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- occlusive conditions
- GLP compliance:
- no
Test material
- Reference substance name:
- Piperidine
- EC Number:
- 203-813-0
- EC Name:
- Piperidine
- Cas Number:
- 110-89-4
- Molecular formula:
- C5H11N
- IUPAC Name:
- piperidine
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Piperidine
- Substance-No.: 77/283
- Physical state: liquid
- Analytical purity: 99 %
- Expiration date of the lot/batch: september 1982
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach am Main, Germany
- Weight at study initiation: 2.39 kg (male); 2.96 kg (female)
- Housing: single
- Diet: Ovator Solikanin 4 mm, Muskator-Werke, Duesseldorf, Germany; ca. 130 g per animal, daily.
- Water: Deionized water (monday to friday); Tap water (weekend); ca 250 ml per animal
- Acclimation period: ca. 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 26
- Humidity (%): 50 - 80
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 3 min, 1 h, 4 h
- Observation period:
- 8 days
- Number of animals:
- 2 (one female and one male)
- Details on study design:
- TEST SITE
- Area of exposure: area of 2.5*2.5 cm on the upper third of the back
- Type of wrap if used: moistened cotton lint, no further data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lutrol, Lutrol:water (1:1)
- Time after start of exposure: 3 min, 1 h and 4 h
SCORING SYSTEM: According to JH Draize: Dermal Toxicity, in: Appraisal of the saftety of chemicals in foods, drugs and cosmetics. p 46 - 59, 1959. Washington, DC: The Association of Food and Drug Officials of the United States of America, Texas, State department of Health.
READINGS
- 15 to 30 minutes after remove of the test substance, as well as after 24, 48 hours and 8 days after application. 8 day reading only with treatment duration of 4 hours.
OTHER
- In case of clinical indication of necrosis, this will be confirmed by macroscopic-pathologic evaluation.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Necrosis
- Remarks on result:
- other: Exposure duration of 3 min led to hard leathery necrosis observed after 24 hours.
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration: 3 min)
- Basis:
- mean
- Remarks:
- (animal 1 and 2)
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Necrosis (leathery, hard), macroscopic-pathologic confirmation
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration: 3 min)
- Basis:
- mean
- Remarks:
- (animal 1 and 2)
- Time point:
- 24/48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration: 1 h)
- Basis:
- mean
- Remarks:
- (animal 1 and 2)
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Necrosis (leathery, hard), macroscopic-pathologic confirmation
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration: 1 h)
- Basis:
- mean
- Remarks:
- (animal 1 and 2)
- Time point:
- 24/48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration: 4 h)
- Basis:
- mean
- Remarks:
- (animal 1 and 2)
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 8 days
- Remarks on result:
- other: Necrosis (leathery, hard and extending beyond the area of application), macroscopic-pathologic confirmation
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration: 4 h)
- Basis:
- mean
- Remarks:
- (animal 1 and 2)
- Time point:
- 24/48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 8 days
- Irritant / corrosive response data:
- The undiluted test substance was applied for 3 min, 1 and 4 h under occlusive conditions to the backs of two rabbits each.Thick and leathery necroses were observed after exposure duration of 3 min; the findings were confirmed histologically.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
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