Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-960-8 | CAS number: 1461-25-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15th July 2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Conducted to a recognised guideline and GLP compliant. Partition coefficients can be influenced by contributions from impurities present in the test substance. Therefore, the reported measured partition coefficient may not accurately reflect the true value for this test substance.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- gas chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 5.07
- Temp.:
- 22 °C
- pH:
- 5.9
- Details on results:
- Preliminary estimate:
Approximate solubility in n-octanol: > 605 g/L
Approximate solubility in water: <4 x 10^3 g/L
Log10 Pow: > 5.18
Definitive Test:
The partition coefficient of the test material has been determined to be greater than 1.19 x 10^5 at 22 degrees C, log 10 Pow > 5.07. - Conclusions:
- The partition coefficient of tetrabutyltin has been determined to be greater than 1.19 x 10^5 at 22 degrees C, log10 Pow > 5.07.
- Executive summary:
The partition coefficient of tetrabutyltin was determined to be greater than 1.19 x 10^5 at 22 degrees C, log10 Pow >5.07, using the shake flask method, Method 107 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Reference
Table 1: Summary of Results
Partition coefficient for each sample | ||||
Sample Number | n-Octanol / Water Volume Ratio | Partition Coefficient | Log10 Pow | Overall Partition Coefficient |
1 | 1:5 | >1.19 x 10^5 | > 5.07 | >1.19 x 10^5 |
2 | >1.19 x 10^5 | > 5.08 | ||
3 | 1:10 | >1.21 x 10^5 | > 5.08 | >1.20 x 10^5 |
4 | >1.20 x 10^5 | > 5.08 | ||
5 | 1:20 | >1.20 x 10^5 | > 5.08 | >1.20 x 10^5 |
6 | >1.20 x 10^5 | > 5.08 |
The linearity of the detector response with respect to concentration for the organic phase analysis matrix was assessed over the nominal concentration range of 0 to 300 mg/L. This was satisfactory with a correlation coefficient of 0.999 being obtained.
The linearity of the detector response with respect to concentration for the aqueous phase analysis matrix was assessed over the nominal concentration range 0 to 10 mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained.
Recovery of analysis of the sample procedure was assessed and proved adequate for the test. At a nominal concentration of 2.5 x 10^-2 mg/L, a mean percentage recovery of 82.0 % was obtained (range 79.5 to 84.3 %). Concentrations have not been corrected for recovery of analysis.
Description of key information
The key study, O'Connor BJ & Mullee DM (2004) was chosen as the study is conducted to a recognised guideline, has a reliability rating 2 according to the criteria of Klimisch et al. (1997) and is the most recent study.
The partition coefficient of tetrabutyltin was determined to be greater than 1.19 x 10^5 at 22 degrees C, log10 Pow >5.07, using the shake flask method, Method 107 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.07
- at the temperature of:
- 22 °C
Additional information
The log Pow for the key study was determined to be greater than 1.19 x 10^5 at 22 degrees C, log10 Pow > 5.07, using the shake flask method, Method 107 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
In a supporting study the log Pow was estimated to be 9.37 according to EPIWIN estimations.
Based on the low water solubility, the "true" octanol-water partition coefficient likely lies between the measured value (>5.07) and the calculated value (9.37). TTBT is relatively insoluble in water and has a strong tendency to sorb to labware. Also, the presence of even a small concentration of a water-soluble impurity significantly increases the amount of tin in the water phase, which reduces the log Pow value. The test substance would need to be purified to >99.999 % to prevent impurities from contributing to the measured result.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.