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Diss Factsheets
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EC number: 246-619-1 | CAS number: 25103-58-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Industrial Biotest Laboratory was found to use fraudulent practices in some of their studies and reports. Since these studies were performed before the implementation of Good Laboratory Practices, it is not possible to verify the scientific credibility of most of these studies.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- OECD 402 requires 5 animals/sex Body weight data of surviving animals not reported. Report does not indicate whether survivors were necropsied.
- GLP compliance:
- no
Test material
- Reference substance name:
- tert-dodecanethiol
- EC Number:
- 246-619-1
- EC Name:
- tert-dodecanethiol
- Cas Number:
- 25103-58-6
- Molecular formula:
- C11H24S to C13H28S
- IUPAC Name:
- 2-methylundecane-2-thiol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 6.83, 10.25, 15.38, 23.07 g/kg (volumes not specified; test substance supplied as liquid)
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- Young albino rabbits, New Zealand strain, were selected as the test animals. The undiluted test material was applied to the shaved backs of four rabbits in each of four groups at dose levels of 6.83, 10.25, 15.38 and 23.07 g/kg of body weight and covered with an occlusive wrapper. After 24 hours of contact, test compound was washed off and the rabbits were observed for 14 days.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 12 600 mg/kg bw
- Mortality:
- All eight of the mid-high (15.38 g/kg) and high dose (23.07 g/kg) group animals died on test. They displayed gradually progressive loss of appetite and weakness. Death occurred three to four days post-dosing.
- Clinical signs:
- other: No untoward effects were noted in any low dose group animals. Mild inactivity lasting up to 36 hours post-dosing was observed in the 10.25 g/kg dose group.
- Gross pathology:
- Necropsy findings were unremarkable, other than the skin reactions, in animals that died on test.
- Other findings:
- Local skin reactions were limited to a moderate erythema and discoloration of the skin at the test substance application site. These reactions occurred throughout all dose groups, and in survivors, disappeared 72 to 96 hours post-dosing.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
Young albino rabbits, New Zealand strain, were selected as the test animals. The undiluted test material was applied to the shaved backs of four rabbits in each of four groups at dose levels of 6.83, 10.25, 15.38 and 23.07 g/kg of body weight and covered with an occlusive wrapper. After 24 hours of contact, test compound was washed off and the rabbits were observed for 14 days.
The acute percutaneous LD50 is considered to be 12.6 g/kg of body weight in albino rabbits. Gross toxic signs consisted of inactivity, loss of appetite and weakness. Local skin reactions at the application site consisted of moderate erythema and discoloration of the skin. Death occurred three to four days after application of the test material. At necropsy no gross pathological findings, other than the skin reactions, were noted.
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