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Diss Factsheets
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EC number: 215-238-2 | CAS number: 1314-61-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Available data on tantalum pentoxide (target substance) indicate a lack of mutagenicity in all available in vitro assays (OECD 471, OECD 473). Additionally data on tantalum pentachloride point to a lack of mutagenicity in in vitro assays according to OECD 476 used in a read-across approach for the assessment of tantalum pentoxide.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
The data available for ditantalum pentaoxide (target substance) does not fulfil all requirements of REACH Annex VIII. Thus, data from tantalum pentachloride were used in a read-across approach. ditantalum pentaoxide was tested negative in a bacterial reverse mutation test (OECD 471; May 2001) and an in vitro chromosome aberration test (OECD 473; Hargitai 2013). Tantalum pentachloride was tested negative in an in vitro HPRT study (OECD 476),
Due to lower transformation/dissolution results for ditantalum pentaoxide than for tantalum pentachloride the resulting toxicity potential would also be expected to be lower. Therefore, the read across to the source substance Tantalum pentachloride is adequately protective. For more details refer to the read-across report attached to IUCLID section 13.
As negative data is available for the higher tier mammalian mutagenicity tests (OECD 473 and OECD 476 with Tantalum pentachloride), ditantalum pentoxide is considered to be non-mutagenic.
Justification for selection of genetic toxicity endpoint
GLP guideline study.
Supporting information
In a literature paper by Keçeli & Alanyali (2004), the cytotoxicity of several metal oxides was examined.
Kidney fibroblast cells from an African Green Monkey were used in the in vitro study. The cells were incubated, in the presence of Tantalum oxide coated glass platelets, for 7 days. The cells where then examined for differences in cell morphology and proliferation. The morphology did not change, although a lower rate of proliferation was seen compared to the control. It was not possible to determine if the test material is toxic to cells.
Justification for classification or non-classification
No genotoxic effects were observed in OECD guideline tests with Ditantalum pentoxide and Tantalum pentachloride. Based on the available data from the read-across partner and itself, Tantalum pentoxide does not warrant classification for mutagenicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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