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Diss Factsheets
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EC number: 203-091-7 | CAS number: 103-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- cytotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature. Original report not available. Insufficient information available for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Bis(2-ethylhexyl) azelate
- Author:
- OECD
- Year:
- 2 006
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 22, Paris, France, 18-21 April, 2006
- Reference Type:
- publication
- Title:
- In vitro comparative toxicity of selected drugs and chemicals in HeLa cells, Chang liver cells, and rat hepatocytes.
- Author:
- Ekwall
- Year:
- 1 982
- Bibliographic source:
- Drug and Chemical Toxicology, 1982, 5(3):219-31
Materials and methods
- Principles of method if other than guideline:
- MIT-24 test system in Hela cells (metabolic inhibition test)
- GLP compliance:
- not specified
- Type of method:
- in vitro
- Endpoint addressed:
- other: cytotoxicity in vitro
Test material
- Reference substance name:
- Bis(2-ethylhexyl) azelate
- EC Number:
- 203-091-7
- EC Name:
- Bis(2-ethylhexyl) azelate
- Cas Number:
- 103-24-2
- Molecular formula:
- C25H48O4
- IUPAC Name:
- bis(2-ethylhexyl) azelate
- Details on test material:
- - Analytical purity: no data
Constituent 1
Test animals
- Species:
- other: Hela cells
Administration / exposure
- Route of administration:
- other: in cell culture medium
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 24 hours
- Post exposure period:
- up to 7 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
no data
Results and discussion
- Details on results:
- The 7-day IC50 for Hela cells varied from 1500 to 20000 mg/L. The test chemical was non-toxic to the cells, probably due to insolubility of the chemical in water.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.