Registration Dossier
Registration Dossier
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EC number: 248-471-3 | CAS number: 27458-94-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 144 mg/kg bw/day
Additional information
Oral
In a two-week oral study, five male rats were dosed by oral gavage with 144 mg/kg bw/day of isononanol. In the control group, ten animals received the vehicle, PEG (polyethylene glycol) 300, daily for 14 days. Animals were sacrificed after 14 days and blood was analyzed for plasma cholesterol and triglycerides. The liver was removed for histopathological analysis, analysis of catalase, and CN-insensitive palmitoyl CoA oxidation. Testicular weight was also determined. Isononanol did not significantly influence bodyweight gain, liver to bodyweight ratio, testis to bodyweight ratio, or palmitoyl CoA oxidase activity. It is concluded that the NOAEL is 144 mg/kg/day.
Justification for classification or non-classification
No classification for repeated dose toxicity is indicated according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labeling and packaging (CLP) regulation (EC) No 1272/2008.
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