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Diss Factsheets
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EC number: 200-658-0 | CAS number: 67-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
An alga growth inhibition test with Pseudokirchneriella subcapitata was performed under static conditions according to OECD 201 and GLP guidelines (reliability 1). Out of a stock solution of 80.0 mg/L five concentrations were tested in a geometrical series. The concentration levels and the control were analytically verified by LC-MS at the start and the end of the 72 hours exposure period.
The test item lowered the pH value of the test solutions at concentrations of nominal 32 and 80 mg/L. The comparison of the results of treatments with and without adjustment of the pH showed that the toxicity is only based on the influence of pH. In the concentrations with adjusted pH no effect was observed up to 89.7 mg/L test substance (measured concentration):
NOEC = 89.7 mg/L (growth rate and inhibition of yield)
EC50 > 89.7 mg/L (growth rate and inhibition of yield)
A higher tier study, short-term toxicity to fish (Danio rerio) performed according to the guideline of the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (Germany) and GLP guideline (reliabilty 1) is available. Seven concentration levels up to 10 000 mg/L (nominal), pH adjusted, were investigated. The concentrations were daily verified analytically. There was no mortality in the control as well as in treated fish at any observation time point. No behaviourial abnormalities were observed during the 96 hour exposure period:
LC0 > 10 000 mg/L
LC50 > 10 000 mg/L
Two trophic levels and taxa were well investigated and covered. An additional study on aquatic invertebrates is scientifically not necessary and a QSAR prediction model using ECOSAR version 1.11 was applied instead.
Prediction: EC50 (daphnia) = 12 964 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.