Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-659-4 | CAS number: 7681-11-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The published literature fulfilled basically scientific principles.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Iodide (in KI) was fed to male and female rats before and during breeding, to females only during gestation and lactation, and to their offspring after weaning (day 21 after birth) through to day 90, at levels of 0, 0.025, 0.05 or 0.1% (w/w) of the diet. The screening test battery of Cincinnati Psychoteratogenicity for rats as the method for assessing the psychotoxic potential of potassium iodide was used to investigate the hazard effects to parents and developmental toxic effects to embryo and offspring in 90 days.
- GLP compliance:
- no
- Remarks:
- Publication
- Limit test:
- no
Test material
- Reference substance name:
- iodide in KI
- IUPAC Name:
- iodide in KI
- Details on test material:
- Food grade potassium iodide (Mallinckrodt Inc.) was purchased from the Tab Chemical Company, Chicago, IL.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- Dietary treatments were given continuously to both males and females for 14 days before mating and for l-14 days during breeding, and to females only during gestation (22 days) and lactation (21 days).
- Duration of treatment / exposure:
- Parents (males and females): 14 days before mating; l-14 days during breeding.
Female only (mother): during gestation (22 days) and lactation (21 days)
Offspring: given dietary potassium iodide, at the level their parents had received, throughout the remainder of the experiment (up to 90 days of age for most animals and somewhat longer for those in avoidance testing). - Frequency of treatment:
- Dietary treatments were given continuously to both males and females for 14 days before mating and for l-14 days during breeding, and to females only during gestation (22 days) and lactation (21 days). After weaning, the offspring were given dietary potassium iodide, at the level their parents had received, throughout the remainder of the experiment (up to 90 days of age for most animals and somewhat longer for those in avoidance testing).
- Duration of test:
- Parents (males and females): 14 days before mating; l-14 days during breeding.
Female only (mother): during gestation (22 days) and lactation (21 days)
Offspring: given dietary potassium iodide, at the level their parents had received, throughout the remainder of the experiment (up to 90 days of age for most animals and somewhat longer for those in avoidance testing).
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
(two control groups) parents
Basis:
nominal in diet
0
- Remarks:
- Doses / Concentrations:
0.025% (w/w)
Basis:
nominal in diet
0.025% (w/w)
- Remarks:
- Doses / Concentrations:
0.05% (w/w)
Basis:
nominal in diet
0.05% (w/w)
- Remarks:
- Doses / Concentrations:
0.1% (w/w)
Basis:
nominal in diet
0.1% (w/w)
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent no treatment
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 1 ppm
- Based on:
- test mat.
- Remarks:
- 0.1 % in diet.
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- NOAEL
- Effect level:
- 1 ppm (nominal)
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects. Remark: There was no evidence suggesting that potassium iodide was embryotoxic. Litter size was significantly reduced, but birth weights and external morphology among those born alive were not significantly altered.
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The concentration up to 142 mg/kg bw of iodide, it just shows no effects to parental reproductivity and teratogenicity to embryo. There was only slight developmental toxicity to growing rats in 90 days, but these effects are not dose related.
- Executive summary:
Potassium iodide (KI) was fed to male and female rats before and during breeding, to females only during gestation and lactation, and to their offspring after weaning (day 21 after birth) through to day 90, at levels of 0, 0.025, 0.05 or 0.1% (w/w) of the diet.
There was no evidence suggesting that potassium iodide was embryotoxic. Litter size was significantly reduced, but birth weights and external morphology among those born alive were not significantly altered.
No change in thyroid weight was observed indicating that these doses were not overtly thyrotoxic. Thyroid hormones were not assessed, however, and it is possible that thyroid function could have been altered in these animals. Nevertheless, the data are consistent with a picture of impaired thyroid function.
Several tests of post-weaning behaviour showed effects at the lowest dose, 0.025 % potassium iodide. M-maze errors were increased at this dose and rotorod performance decreased. However, because these effects were not found at the higher doses it appears unlikely that they were related to potassium iodide. At present, these effects can only described as 'false positives'.
The only effect on post-weaning behaviour that appeared to be consistently related to potassium iodide exposure was the reduction in nocturnal running-wheel activity found among the tested females. It may be that female cyclicity makes them more sensitive to the influence of chronic moderate iodide exposure than males and this could explain the contrast with the results of an acute test of activity and exploration, the open-field test, on which no consistent iodide-related effects were found.Therefore it can be concluded that the iodide is not reproductive, embryonic toxicity, and developmental toxicity at dose of 0.1% in diet.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.