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Diss Factsheets
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EC number: 203-475-4 | CAS number: 107-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards (restrictions: no details about test substance)
Data source
Reference
- Reference Type:
- publication
- Title:
- Determination of the kinetic constants for metabolism of inhaled toxicants in vivo using gas uptake measurements.
- Author:
- Andersen ME, Gargas ML, Jones RA, Jenkins LJ
- Year:
- 1 980
- Bibliographic source:
- Toxicol Appl Pharmacol 54: 100-116.
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Saturable inhalation uptake in rats measured
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl vinyl ether
- EC Number:
- 203-475-4
- EC Name:
- Methyl vinyl ether
- Cas Number:
- 107-25-5
- Molecular formula:
- C3H6O
- IUPAC Name:
- methoxyethene
- Details on test material:
- commercially available in pressurized cylinders
no further details
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- body weight 180-280 g
water and diet ad libitum
acclimatisation: several days
no further data
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: air
- Details on exposure:
- rats exposed in 31-liter battery jar chambers origin; whole body exposure.
Analytical control every 5 min starting 10 min after initiation of exposure - Duration and frequency of treatment / exposure:
- 3 h; single exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100, 300, 1000, 3000 ppm (240, 720, 2400, 7200 mg/m³)
- No. of animals per sex per dose / concentration:
- 9
- Details on study design:
- gas uptake and metabolism in a whole body inhalation chamber measured
- Details on dosing and sampling:
- percentage loss of initial concentration versus time was measured every 10 min adjusted for the unoccupied chamber loss rate.
- Statistics:
- means calculated
kinetic parameters calculated
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The uptake of MVE was saturable. The plot uptake rate vs. ambient concentration resembled a theoretical Michaelis-Menten-plot. The data were plotted according to a modified Eadie-Hofstee plot. The best fit straight line (correlation r²= 0.99) gave the following results:
Michaelis constant Km = 462 ppm (i.e. the concentration of MVE at which uptake proceeds at half maximal velocity)
Vmax. (the maximal rate of gas uptake from the 31-l inhalation chamber used) was 176 ppm/kg bw/hr, equivalent to 12.9 mg MVE/kg bw/hr. - Details on distribution in tissues:
- no data
- Details on excretion:
- no data
Metabolite characterisation studies
- Details on metabolites:
- no data
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: uptake of MVE is depending on the velocity of the enzymatic metabolism
Saturable inhalation uptake in rats was reported. - Executive summary:
The saturable inhalation uptake in male F344 rats was measured during 3 h exposure in a 31-liter battery jar chambers (100, 300, 1000, 3000 ppm [240, 720, 2400, 7200 mg/m³] for 180 min; whole body exposure). Data were transformed by modified Eadie-Hofstee plots to calculate the kinetic parameters. The concentration at which the uptake proceeds at half maximal velocity was Km = 462 ppm; the maximal gas uptake was Vmax= 176 ppm/kg bw/hour, i.e. 12.9 mg/kg bw/hour.
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