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Diss Factsheets
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EC number: 247-045-4 | CAS number: 25498-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
A GLP-study equivalent to OECD guideline 417 is available for tripropylene glycol methyl ether. TPGME was rapidly distributed and quickly metabolized and eliminated from animals. TPGME is metabolized extensively. Less than 5 per cent of the high dose was recovered as unchanged TPGME.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 20
- Absorption rate - inhalation (%):
- 100
Additional information
Both oral and inhalation absorption rates were set at 100%, whereas dermal absorption rate set at 20%. For detailed information, refer to read-across justification document for P-series glycol ethers.
Tripropylene glycol methyl ether (TPGME) was rapidly distributed and quickly metabolized and eliminated from the test animals. Tripropylene glycol, dipropylene glycol and propylene glycol as well as an oxidation product of dipropylene glycol, dipropylene glycol monomethyl ether (DPGME), TPGME and the sulfate conjugate of TPGME were identified in the urine, less than 5 per cent of the high dose was recovered as unchanged TPGME. These results indicate that TPGME is metabolized extensively and is comparable to DPGME in disposition and types of metabolites.
Discussion on bioaccumulation potential result:
Tripropylene glycol methyl ether (TPGME) was rapidly distributed and quickly metabolized and eliminated from the test animals. Tripropylene glycol, dipropylene glycol and propylene glycol as well as an oxidation product of dipropylene glycol, dipropylene glycol monomethyl ether (DPGME), TPGME and the sulfate conjugate of TPGME were identified in the urine, less than 5 per cent of the high dose was recovered as unchanged TPGME. These results indicate that TPGME is metabolozed extensively and is comparable to DPGME in disposition and types of metabolites. Overall, no bioaccumulation potential is expected for TPGME and other glycol ethers.
As a class, the propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure. For detailed information, refer to read-across justification document for P-series glycol ethers. While not tested directly, absorption by inhalation exposure also would be expected to be rapid for PGEs aerosols that are in the respirable range. Dermal absorption is expected to be somewhat slower but, once absorbed, subsequent distribution also should be rapid. Most of the PGE dose would be rapidly excreted. Most excretion for PGEs is via the urine and expired air. A small portion is excreted in the feces.
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