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Diss Factsheets
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EC number: 206-059-0 | CAS number: 298-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: EPA standard method, but some minor deficiencies in reporting
- Qualifier:
- according to guideline
- Guideline:
- other: Standard test method used: USEPA (1991), Methods for measuring the acute toxicity of effluents to freshwater and marine organisms, 4th ed. EPA/600/4-90/027, U.S. Environmental Protection Agency, Washington DC
- Deviations:
- yes
- Remarks:
- Ceriodaphnia were fed during the test. Preliminary tests with and without feeding had shown that this would not influence the results.
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Test organisms (species):
- Ceriodaphnia dubia
- Details on test organisms:
- - Source, supplier, any pretreatment, breeding method: in-house cultures (ENSR Consulting and Engineering, Ford Collins, Colorado, USA), cultured in hard reconstituted water or 20% mineral water according to the mentioned EPA-method at 25 °C
- Feeding: 100 µl of a 1:1 mix of yeast/cerophyl/trout chow and algal suspension was added to each test chamber at test initiation
- Age at study initiation: less than 24 h - Test type:
- static
- Limit test:
- no
- Details on test conditions:
- - Stock solutions preparation: Stock solutions were prepared by dissolving 10,000 mg KHCO3 in one l MHRW. Test solutions were prepared by serially diluting the 10,000-mg/l stock solution with MHRW to develop a series of test concentrations spaced on a 0.5 x dilution factor (i.e. 10,000, 5,000, 2,500, 1,250 mg/l). As testing proceeded and effect thresholds were determined, test concentrations were often spaced much more closely (e.g. 2,500, 2,000, 1,500, 1,000, 500 mg/l) to better define responses near the effect threshold.
- Test temperature range: 25°C
- Exposure vessel type: 30-ml plastic beakers containing 10 ml of test solution and five organisms per chamber
- Dilution water source: not reported - Dilution water chemistry: moderately hard reconstituted water (MHRW)
- Lighting: 16h:8h light:dark photoperiod
- Water chemistry in test: Measured dissolved oxygen concentrations were always within acceptable range (> 40% saturation). Measured pH varied according to the components of the solution but was generally between ph 7.5 and 9.0.
- Element (unit) basis: immobilisation
- Test design: 2 to 3 replicates
- Exposure period: 24 and 48 hours - Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 630 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 630 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Reported statistics and error estimates:
- EC50 concentrations were calculated using a computer program following the trimmed Spearman-Karber method.
Data was entered into a database using Paradox 3.1 software (Borland International, Scotts Valley, CA, USA). - Validity criteria fulfilled:
- not specified
- Conclusions:
- In a 48-h acute toxicity study, Ceriodaphnia dubia were exposed to KHOC3. The 48-h EC50 was 630 mg a.i./L.
- Executive summary:
The 48 –hr-acute toxicity of KHCO3 to Ceriodaphnia dubia was studied under static conditions. Daphnids were exposed to at nominal concentrations of 500, 1000, 1500, 2000, 2500 mg a.i./L under static conditions. The 96-h LC50was 630 mg a.i./L
This study is classified as acceptable with restrictions and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Results Synopsis
Test Organism Age (e.g. 1stinstar): <24 hours
Test Type (Static): EPA/600/4-90/027 (USEPA 1991)
EC50: 630mg a.i./L
Endpoint(s) Effected: mobility
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: EPA standard method, but some minor deficiencies in reporting
- Qualifier:
- according to guideline
- Guideline:
- other: Standard test method used: USEPA (1991), Methods for measuring the acute toxicity of effluents to freshwater and marine organisms, 4th ed. EPA/600/4-90/027, U.S. Environmental Protection Agency, Washington DC
- Deviations:
- yes
- Remarks:
- Daphnids were fed during the test. Preliminary tests with and without feeding had shown that this would not influence the results.
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Source, supplier, any pretreatment, breeding method: in-house cultures (ENSR Consulting and Engineering, Ford Collins, Colorado, USA), cultured in hard reconstituted water according to the mentioned EPA-method at 20 °C
- Feeding: 100 µl of a 1:1 mix of yeast/cerophyl/trout chow and algal suspension was added to each test chamber at test initiation
- Age at study initiation: less than 24 h - Test type:
- static
- Limit test:
- no
- Details on test conditions:
- - Stock solutions preparation: Stock solutions were prepared by dissolving 10,000 mg KHCO3 in one l MHRW. Test solutions were prepared by serially diluting the 10,000-mg/l stock solution with MHRW to develop a series of test concentrations spaced on a 0.5 x dilution factor (i.e. 10,000, 5,000, 2,500, 1,250 mg/l). As testing proceeded and effect thresholds were determined, test concentrations were often spaced much more closely (e.g. 2,500, 2,000, 1,500, 1,000, 500 mg/l) to better define responses near the effect threshold.
- Test temperature range: 20 °C
- Exposure vessel type: 30-ml plastic beakers containing 10 ml of test solution and five organisms per chamber
- Dilution water source: not reported
- Dilution water chemistry: moderately hard reconstituted water (MHRW)
- Lighting: 16h:8h light:dark photoperiod
- Water chemistry in test: Measured dissolved oxygen concentrations were always within acceptable range (> 40% saturation). Measured pH varied according to the components of the solution but was generally between ph 7.5 and 9.0.
- Element (unit) basis: immobilisation
- Test design: 4 replicates
- Exposure period: 24 and 48 hours - Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 650 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: IUCLID4 note: "m" (measured/nominal)
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 670 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: IUCLID4 note: "m" (measured/nominal)
- Reported statistics and error estimates:
- EC50 concentrations were calculated using a computer program following the trimmed Spearman-Karber method. Data was entered into a database using Paradox 3.1 software (Borland International, Scotts Valley, CA, USA).
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In a 48-h acute toxicity study, water fleas (Daphnia magna) were exposed to KHOC3. The 48-h EC50 was 650 mg a.i./L.
- Executive summary:
The 48 –hr-acute toxicity of KHCO3 to water flea Daphnia magna was studied under static conditions. Daphnids were exposed to nominal concentrations of 500, 1000, 1500, 2000, 25000 mg a.i./L under static conditions. The 48-h LC50was 650 mg a.i./L
This study is classified as acceptable with restrictions and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Results Synopsis
Test Organism Age (e.g. 1stinstar): <24 hours
Test Type (Static): EPA/600/4-90/027 (USEPA 1991)
EC50: 650mg a.i./L
Endpoint(s) Effected: mobility
Referenceopen allclose all
RESULTS - EXPOSED:
- Nominal/measured concentrations: All ions concentrations measured in stock solutions were compared to nominal values. If the measured concentrations differed from the nominal value by more than 20%, the actual measured concentrations were substituted for the nominal concentrations.
- Effect data (Immobilisation):
-- 48 h EC50 = 630 (580-670) mg/l (arithmetic mean of 43replicates (range) expressed as total ion concentrations added)
-- 24 h EC50 = 630 (580-670) mg/l (arithmetic mean of 2 replicates (range) expressed as total ion concentrations added)
RESULTS - EXPOSED:
- Nominal/measured concentrations: All ions concentrations measured in stock solutions were compared to nominal values. If the measured concentrations differed from the nominal value by more than 20%, the actual measured concentrations were substituted for the nominal concentrations.
- Effect data (Immobilisation):
-- 48 h EC50 = 650 (380-820) mg/l (arithmetic mean of 4 replicates (range) expressed as total ion concentrations added)
-- 24 h EC50 = 670 (440-880) mg/l (arithmetic mean of 4 replicates (range) expressed as total ion concentrations added)
Description of key information
The 48-h EC50 for Ceriodaphnia dubia is 630 mg a.i./L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 630 mg/L
Additional information
In a 48-h acute toxicity study, water fleas (Daphnia magna) and Ceriodaphnia dubia were exposed to KHCO3. The 48-h EC50 were 650 mg a.i./L. and 630 mg a.i./L, respectively. The 48h EC 50 of Ceriodaphnia dubia was somewhat lower. Therefore this value is used for the assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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