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Diss Factsheets
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EC number: 253-168-4 | CAS number: 36727-29-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
3,5,5 trimethylhexanoyl chloride is very toxic at inhalation and of moderate toxicity after swallowing.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 700 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 0.24 mg/m³ air
Additional information
oral:
An acute oral toxicity study similar to OECD 401 with acceptable restrictions mostly due to reduced reporting in times before GLP was performed. Groups of 5 rats per sex and dose were administered with 3160, 2150, 1470, 1000 mg/kg of the test substance. The acute oral LD50 for male and female rats is ca. 1700 mg/kg after oral application (BASF 1979).
inhalation:
Five rats per sex and dose were exposed to 0.1, 0.24 and 0.45 mg/L (vapor; analytical conc.) for 1h in an OECD 403 guideline study. Irregular and accelerated respiration as well as eyelid closure, restlessness followed by apathy and abdominal position was observed. Necropsy of the animals that died showed general congestion (all animals) and intensified hyperemia of the lungs.
No macroscopic pathologic findings were noted in the animals killed at the end of the study. Combined LC50 value is about 0.24 mg/L/1h (BASF 1994)
Comparable results (LC50 0.1 mg/L/4h) were achieved in an non GLP study (BASF 1979).
Justification for classification or non-classification
According to the results the substance is classified as very toxic by inhalation cat 1 (H302) and harmful after swallowing cat 4 (H330) according of regulations 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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