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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally accepted scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
Six groups of 10 male young adult Wister rats (avarage weight 191 g) each reveived per gavage a single dose of 100, 200, 300, 400, 500 or 600 µl/kg bw tert-butylisocyanate. The animals were observed for mortality, weight and clinical signs through day 14.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
tert-butyl isocyanate
EC Number:
216-544-9
EC Name:
tert-butyl isocyanate
Cas Number:
1609-86-5
Molecular formula:
C5H9NO
IUPAC Name:
2-isocyanato-2-methylpropane

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
100, 200, 300, 400, 500 or 600 µg/kg bw = 84, 168, 252, 336, 420, 504 mg/kg bw

density = 0.84 g/cm³
No. of animals per sex per dose:
10 male rats/dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
185 mg/kg bw

Any other information on results incl. tables

A single dose of 200 to 600 µl/kg bw tert-butylisocynante caused to following signs of intoxication: sedation, cyanosis, disordered breathing and a reduction of general condition. Additional, with doses of 200 to 400 µl/kg bw a weight reduction was observed.

Symptoms were evident 1 hour after application and continued until the last day of the examination period. Deads occured after 3 hours until day 3.

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information
Executive summary:

Six groups of 10 male young adult Wister rats (avarage weight 191 g) each reveived per gavage a single dose of 100, 200, 300, 400, 500 or 600 µl/kg bw = (84, 168, 252, 336, 420, 504 mg/kg bw) tert-butylisocyanate. The animals were observed for mortality, weight and clinical signs through day 14.

A single dose of 200 to 600 µl/kg bw tert-butylisocynante caused to following signs of intoxication: sedation, cyanosis, disordered breathing and a reduction of general condition. Additional, with doses of 200 to 400 µl/kg bw a weight reduction was observed.

Symptoms were evident 1 hour after application and continued until the last day of the examination period. Deads occured after 3 hours until day 3. A single dose of 84 mg/kg bw tert-butylisoyanate was tolerated by male rats without symptoms.

LD50 = 220 µ/kg bw tert-butylisocyanate = 185 mg/kg bw (rats, male)