Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 249-482-6 | CAS number: 29171-20-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978, other details not available
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Scoring system is not in line with nowadays system
- GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- 3,7-dimethyloct-6-en-1-yn-3-ol
- EC Number:
- 249-482-6
- EC Name:
- 3,7-dimethyloct-6-en-1-yn-3-ol
- Cas Number:
- 29171-20-8
- Molecular formula:
- C10H16O
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-yn-3-ol
- Reference substance name:
- 29717-20-8
- IUPAC Name:
- 29717-20-8
- Details on test material:
- Not applicable
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M. Gaukler, 6050 Offenheim
- Weight at study initiation: 3.1kg
- Diet: ad libitum
- Water: ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- The test substance (0.5 mL) was applied to shaved back of 4 rabbits. The test substance was applied on a gauze pad with an area of approximately 4 cm2. The gauze pad was occluded. After 4 hours, the test substance was removed by washing the test site with water/lutrol (1/1). The site was dried. After removal skin was scored for erythema and edema (4h, 24h, 48, and 8 days). The following scoring system was used: 0 (no reaction), 1 (questionable), 2 (mild).
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 8 days
- Number of animals:
- 4
- Details on study design:
- No remarks
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 48 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 48 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- Scaling observed after 8 days.
- Other effects:
- No clinical signs for systemic toxicity were noted.
Any other information on results incl. tables
All animals at all scoring points showed grade 2 (mild) scores for erythema. This was accompanied by strong scaling on day 8. Edema (grade 2) were noted in 2 of 4 animals after 4h, in all animals after 24 and 48 h. On day 8 grade 1 edema (3 of 4 animals) and grade 2 edema (1 of 4 animals) were noted.
Animal Number |
4h |
24h |
48h |
8d |
Mean (24-48h) |
erythema |
|
|
|
|
|
1 |
2 |
2 |
2 |
2 (S) |
2 |
2 |
2 |
2 |
2 |
2 (sS) |
2 |
3 |
2 |
2 |
2 |
2 (sS) |
2 |
4 |
2 |
2 |
2 |
2 (sS) |
2 |
edema |
|
|
|
|
|
1 |
0 |
2 |
2 |
2 |
2 |
2 |
0 |
2 |
2 |
1 |
2 |
3 |
2 |
2 |
2 |
1 |
2 |
4 |
2 |
2 |
2 |
1 |
2 |
(sS) = severe scaling, (S) = Scaling
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The results strongly suggest that Dehydrolinalool should be considered a skin irritant
- Executive summary:
Although group mean scores from 24 to 72 h cannot be calculated the results strongly suggest that Dehydrolinalool should be considered a skin irritant especially in the light of irreversibility within 8 days.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.