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EC number: 222-598-4 | CAS number: 3547-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
ACUTE ORAL toxicity LD50 value (mg/kg): >5000
ACUTE DERMAL toxicity LD50 value (mg/kg): >2000
ACUTE INHALATION toxicity 4-hour rat LC50 value (mg/L): >6.12 (aerosol)
Key value for chemical safety assessment
Additional information
The lowest reported oral LD50 is >5000 mg/kg in rats. One female was found dead on Day 2. Clinical signs observed in both sexes were ruffled fur, diarrhea, dark stained muzzle, and anogenital staining. By Day 6, all rats recovered from the above conditions and appeared active and healthy for the remainder of the 14-day observation period. No treatment-related gross pathology was observed at termination (US EPA 1995). In the other acute oral toxicity study in rats, the oral LD50 is 8530 mg/kg. The rats in all but the lowest dose group became sick and ataxic immediately following oral administration of the test substance. All of the rats died in the two highest dose levels (15.8 and 31.6 mg/kg). The surviving rats in the two lower dose groups (3.98 and 7.95 mg/kg) were sluggish the first day but recovered fully thereafter and showed good weight gains during the 14 -day observation period. No treatment-related gross pathology was observed in the surviving animals at termination. (Industrial Hygiene Foundation America, Inc., 1957).
A dermal LD50 of >2000 mg/kg was determined for rabbits. Well defined erythema with severe edema and eschar at 4 days. Body weight loss was seen in 4/5 males and 4/5 females on Day 7, and in 2/5 males and 4/5 females on Day 14. Decreases in body weight gain were seen in 2/5 males and 4/5 females during the 14 day period. While no clinical signs were seen in males, 1-4 females exhibited tremors, lethargy, signs of diarrhea, no feces or thin appearance on Days 6 through 14. Gross necropsy revealed a lower gastrointestinal tract full of gas, mucus and dark liquid in two males and three females. The results of this study determined that the acute dermal LD50 was greater than 2000 mg/kg for both sexes (U.S. EPA, 1995).
Sprague-Dawley rats (5/sex) were exposed to aerosol concentrations of undiluted technical hydroxyethyl octyl sulfide (96.1%) at a mean analytical concentration of 6.12 ± 0.16 mg/L with a mass median aerodynamic diameter (MMAD) particle size distribution of 2.0 ± 0.03 μM for 4 hours. The acute inhalation LC50 was >6.12 mg/L for both sexes (U.S. EPA, 1995).
Justification for classification or non-classification
Acute Oral
Classification proposal regarding acute oral toxicity: DSD: None. GHS/CLP: None.
Acute Inhalation
Classification proposal regarding acute inhalation toxicity: DSD: None. GHS/CLP: None.
Acute Dermal
Classification proposal regarding acute dermal toxicity: DSD: None. GHS/CLP: None.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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