Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-589-7 | CAS number: 1897-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
SKIN
Not irritating, male rabbit; OECD 404; Janssen and van Doorn, 1992a
EYE
Not irritating, male rabbit; OECD 405; Janssen and van Doorn, 1992b
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin
In the key study, three rabbits received a single four hour application of 0.5g of the test material and were assessed for at 30 minutes, 24, 48 and 72 hours after treatment for any signs of skin irritation. Very slight erythema was seen in all animals 30 minutes after removal of test material and very slight erythema was seen in one animal after 24 hours. There were no other signs of skin irritation. The study was performed in line with GLP, to a standardised guideline and with a high standard and as such was assigned a reliability score of 1.
Supporting information is available in the form of a study in which the test material was applied to abraded and non abraded skin of three rabbits for five consecutive days. Readings of the reactions were made every 24 hours up to 10 days after first application. Under the conditions of the study, the test material did not elicit any reaction in any of the animals. The study was not performed to GLP but was conducted in line with solid scientific principles and as such was assigned a reliability score of 2.
Eye
In the key study, 0.1 ml of test material was placed into the conjunctival sac of one eye of each of three male rabbits. The eyes of the rabbits were examined and the ocular reactions graded at 24 hour intervals up to and including 72 hours post treatment. At 24 hours after application of the test material a fold of the cornea across the whole eye was observed in one rabbit. No adverse effects were observed hereafter. The study was performed in line with GLP, to a standardised guideline and with a high standard and as such was assigned a reliability score of 1.
Supporting information is available in the form of a study in which the test material was placed into the conjunctival sac of eight male rabbits. The treated eye of five animals were rinsed with 300 ml of lukewarm water 5 minutes after installation of the test material. The treated eyes of the remaining three animals were rinsed in the same way 24 hours after installation. Readings of reaction of all animals were made at 1, 24, 48, 72 and 96 hours and at 7 days after installation of the test material. At 1 hour after application of the test material a slight redness of the conjunctivae was apparent in all animals of both groups; no adverse effects were observed hereafter. The study was not performed to GLP but was conducted in line withsolidscientific principles and as such was assigned a reliability score of 2.
Overall, the results of not irritating were consistent over all studies and considered suitable for assessment as an accurate reflection of the test material. The available data is considered to be complete and the conclusion for both skin irritation and corrosion, and eye irritation, not irritating, was taken forward for risk assessment.
Justification for classification or non-classification
Under the conditions of the studies, the test material is considered to be practically non-irritating to the skin and eye and does not require classification for skin irritation in line with Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.