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EC number: 234-148-4 | CAS number: 10563-29-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1991-02-01 to 1991-06-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, OECD guideline n°404 (1981 May 12th)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- N'-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine
- EC Number:
- 234-148-4
- EC Name:
- N'-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine
- Cas Number:
- 10563-29-8
- Molecular formula:
- C8H21N3
- IUPAC Name:
- {3-[(3-aminopropyl)amino]propyl}dimethylamine
- Details on test material:
- - Name of test material (as cited in study report): Dimethyldipropylenetriamine
- Substance type: pure active substance
- Physical state: liquid
- Analytical purity: 99.49%
- Purity test date: 1991-01-22
- Lot/batch No.: P90.11
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: stored at romm temperature and kept away from light
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage cunicole du val de Selle, 80160 Prouzel, France
- Age at study initiation: no data
- Weight at study initiation: 2500+/-100 g
- Housing: individually
- Diet (e.g. ad libitum): ad libitum pellet diet "Rabbits sustenanceref.112C (U.A.R., 91360 Villemoisson-sur-Orge, France)"
- Water (e.g. ad libitum): ad libitum tap water filtered by a 0.22µ filter membrane (Cociété Millipore, 78140 Vélizy, France)
- Acclimation period: at least 5 days before treatment
- Other: Male rabbits were used
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20+/-3°C
- Humidity (%): 50+/-20%
- Air changes (per hr): non recycled and filtered with absolute filters
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5mL undiluted - Duration of treatment / exposure:
- 4 hours (n=3) and 3 minutes (n=1)
- Observation period:
- 1, 24, 48, 72hours then daily until day 15
- Number of animals:
- 4 in total
- Details on study design:
- TEST SITE
- Area of exposure: 6cm² dry gauze patch (Semes France, 54183 Heillecourt, France)
- Type of wrap if used: adhesive hypoallergenic aerated semi-occlusive dressing (Laboratoires de Pansements et d'hygiène, 21300 Chenôve, France) attached to a gauze bandage (Promotion médicale, 27000 Evreux, France)
SCORING SYSTEM: according to the OECD guideline n° 404 (1981 May 12th)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 4-hour exposure
- Basis:
- animal: #1, 2 and 3
- Time point:
- other: 24, 48 hours
- Reversibility:
- not reversible
- Remarks:
- , sacrificed on D2 for humanitarian reasons
- Remarks on result:
- other: Necrosis
- Irritation parameter:
- edema score
- Remarks:
- 4-hour exposure
- Basis:
- animal #1
- Time point:
- other: 24, 48 hours
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- 4-hour exposure
- Basis:
- animal: #2 and 3
- Time point:
- other: 24, 48 hours
- Score:
- 4
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Remarks:
- 3-min exposure
- Basis:
- animal #4
- Time point:
- other: D1 to D15
- Reversibility:
- not reversible
- Remarks on result:
- other: Necrosis
- Irritation parameter:
- edema score
- Remarks:
- 3-min exposure
- Basis:
- animal #4
- Time point:
- other: 24, 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritant / corrosive response data:
- The application of the test substance during 4 hours (animals O1 to O3) has induced a tissular destruction on the whole depth of the skin the 3 animals which were sacrificed for humanitarian reasons.
After the application of the test substance during 3 minutes (animal O4), severe erythema to slight eschar formation (superficial necrosis) was observed after one hour and then was irreversible during 14 days. A slight oedema (score 2) was noted during 24 hours.
Any other information on results incl. tables
Individual scoring
TD=Tissue Destruction N=Necrosis
|
D1 |
D2 |
D3 |
D4 |
D5 |
D6 |
D7 |
D8 |
D9 |
D10 |
D11 |
D12 |
D13 |
D14 |
D15 |
Erythema |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
O1 |
TD |
TD |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
O2 |
TD |
TD |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
O3 |
TD |
TD |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
O4 |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
N |
Oedema |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
O1 |
2 |
2 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
O2 |
4 |
4 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
O3 |
4 |
4 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
O4 |
2 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- DIMETHYLDIPROPYLENETRIAMINE has to be labelled as corrosive in rabbits.
- Executive summary:
The acute dermal irritation of Dimethyldipropylenetriamine (DMAPAPA) was evaluated in male New Zealand White rabbits according to OECD N° 404 Guideline. 0,5mL of DMAPAPA was applied during 4 hours in 3 rabbits and during 3 minutes in 1 rabbit on clipped area. The cutaneous reaction was observed 1, 24, 48, 72 hours after removal of the dressing and then daily to day 15 (for 1 animal).
After application of the substance during 4 hours, tissular destruction on the whole depth of the skin was observed in the three animals, which were sacrificed for ethical reasons. The application of DMAPAPA during 3 minutes induced a severe erythema and a slight eschar formation in 1 hour that were irreversible during 14 days. A slight oedema was noted during 24 hours.
Under these experimental conditions, DMAPAPA has to be classified as corrosive in rabbits.
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